RT Journal Article
T1 Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition.
A1 Park, Jin Young
A1 Bueno-de-Mesquita, H Bas
A1 Ferrari, Pietro
A1 Weiderpass, Elisabete
A1 de Batlle, Jordi
A1 Tjønneland, Anne
A1 Kyro, Cecilie
A1 Rebours, Vinciane
A1 Boutron-Ruault, Marie-Christine
A1 Mancini, Francesca Romana
A1 Katzke, Verena
A1 Kühn, Tilman
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 La Vecchia, Carlo
A1 Kritikou, Maria
A1 Masala, Giovanna
A1 Pala, Valeria
A1 Tumino, Rosario
A1 Panico, Salvatore
A1 Peeters, Petra H
A1 Skeie, Guri
A1 Merino, Susana
A1 Duell, Eric J
A1 Rodríguez-Barranco, Miguel
A1 Dorronsoro, Miren
A1 Chirlaque, Maria-Dolores
A1 Ardanaz, Eva
A1 Gylling, Björn
A1 Schneede, Jörn
A1 Ericson, Ulrika
A1 Sternby, Hanna
A1 Khaw, Kay-Tee
A1 Bradbury, Kathryn E
A1 Huybrechts, Inge
A1 Aune, Dagfinn
A1 Vineis, Paolo
A1 Slimani, Nadia
K1 EPIC study
K1 dietary folate intake
K1 pancreatic cancer
AB Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/day) compared to the lowest (
YR 2018
FD 2018-12-21
LK http://hdl.handle.net/10668/12900
UL http://hdl.handle.net/10668/12900
LA en
DS RISalud
RD Apr 5, 2025