RT Journal Article
T1 Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study.
A1 de Rojas, Itziar
A1 Hernández, Isabel
A1 Montrreal, Laura
A1 Quintela, Inés
A1 Calero, Miguel
A1 Royo, Jose Luís
A1 Huerto Vilas, Raquel
A1 González-Pérez, Antonio
A1 Franco-Macías, Emilio
A1 Macías, Juan
A1 Menéndez-González, Manuel
A1 Frank-García, Ana
A1 Diez-Fairen, Mónica
A1 Lage, Carmen
A1 García-Madrona, Sebastián
A1 Aguilera, Nuria
A1 García-González, Pablo
A1 Puerta, Raquel
A1 Sotolongo-Grau, Oscar
A1 Alonso-Lana, Silvia
A1 Rábano, Alberto
A1 Arias Pastor, Alfonso
A1 Pastor, Ana Belén
A1 Corma-Gómez, Anaïs
A1 Martín Montes, Angel
A1 Martínez Rodríguez, Carmen
A1 Buiza-Rueda, Dolores
A1 Periñán, Maria Teresa
A1 Rodriguez-Rodriguez, Eloy
A1 Alvarez, Ignacio
A1 Rosas Allende, Irene
A1 Pineda, Juan A
A1 Bernal Sánchez-Arjona, María
A1 Fernández-Fuertes, Marta
A1 Mendoza, Silvia
A1 Del Ser, Teodoro
A1 Gr Ace/Degesco Consortium, 
A1 Garcia-Ribas, Guillermo
A1 Sánchez-Juan, Pascual
A1 Pastor, Pau
A1 Bullido, María J
A1 Álvarez, Victoria
A1 Real, Luis M
A1 Mir, Pablo
A1 Piñol-Ripoll, Gerard
A1 García-Alberca, Jose María
A1 Medina, Miguel
A1 Orellana, Adelina
A1 Butler, Chris R
A1 Marquié, Marta
A1 Sáez, María Eugenia
A1 Carracedo, Ángel
A1 Tárraga, Lluís
A1 Boada, Mercè
A1 Ruiz, Agustín
K1 APOE
K1 COVID-19
K1 GR@ACE/DEGESCO
K1 GWAS
K1 SARS-CoV-2
K1 dementia
AB Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.
SN 2075-4426
YR 2021
FD 2021-12-07
LK https://hdl.handle.net/10668/27278
UL https://hdl.handle.net/10668/27278
LA en
DS RISalud
RD Apr 5, 2025