%0 Journal Article
%A de Rojas, Itziar
%A Hernández, Isabel
%A Montrreal, Laura
%A Quintela, Inés
%A Calero, Miguel
%A Royo, Jose Luís
%A Huerto Vilas, Raquel
%A González-Pérez, Antonio
%A Franco-Macías, Emilio
%A Macías, Juan
%A Menéndez-González, Manuel
%A Frank-García, Ana
%A Diez-Fairen, Mónica
%A Lage, Carmen
%A García-Madrona, Sebastián
%A Aguilera, Nuria
%A García-González, Pablo
%A Puerta, Raquel
%A Sotolongo-Grau, Oscar
%A Alonso-Lana, Silvia
%A Rábano, Alberto
%A Arias Pastor, Alfonso
%A Pastor, Ana Belén
%A Corma-Gómez, Anaïs
%A Martín Montes, Angel
%A Martínez Rodríguez, Carmen
%A Buiza-Rueda, Dolores
%A Periñán, Maria Teresa
%A Rodriguez-Rodriguez, Eloy
%A Alvarez, Ignacio
%A Rosas Allende, Irene
%A Pineda, Juan A
%A Bernal Sánchez-Arjona, María
%A Fernández-Fuertes, Marta
%A Mendoza, Silvia
%A Del Ser, Teodoro
%A Gr Ace/Degesco Consortium,
%A Garcia-Ribas, Guillermo
%A Sánchez-Juan, Pascual
%A Pastor, Pau
%A Bullido, María J
%A Álvarez, Victoria
%A Real, Luis M
%A Mir, Pablo
%A Piñol-Ripoll, Gerard
%A García-Alberca, Jose María
%A Medina, Miguel
%A Orellana, Adelina
%A Butler, Chris R
%A Marquié, Marta
%A Sáez, María Eugenia
%A Carracedo, Ángel
%A Tárraga, Lluís
%A Boada, Mercè
%A Ruiz, Agustín
%T Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study.
%D 2021
%@ 2075-4426
%U https://hdl.handle.net/10668/27278
%X Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.
%K APOE
%K COVID-19
%K GR@ACE/DEGESCO
%K GWAS
%K SARS-CoV-2
%K dementia
%~