RT Journal Article
T1 One-Year, Efficacy and Safety Open Label Study, with a Single Injection of a New Hyaluronan for Knee OA: The SOYA Trial.
A1 Gavín, Carlos
A1 J Blanco, Francisco
A1 L Pablos, José
A1 Caracuel, Miguel A
A1 Rosas, José
A1 Gómez-Barrena, Enrique
A1 Navarro, Francisco
A1 Coronel, María Pilar
A1 Gimeno, Mercedes
K1 hyaluronic acid
K1 osteoarthritis
K1 pain
K1 viscosupplementation
AB To assess the efficacy and safety of a single injection of a new formulation of hyaluronic acid (MPS-HA2%) in patients with symptomatic knee osteoarthritis after 12 months' follow-up. Prospective, single-arm, multicentre, open-label, 12-month follow-up study. Patients with Kellgren-Lawrence (KL) 2-3 and visual analogue scale (VAS) pain scores of ≥40- A total of 101 patients (mean age: 68 years; 74% female; and 78% overweight) were included. The mean reduction in pain at 12 months was 37.7%; the total WOMAC score improved by 36.5% and the pain, stiffness and physical function subscores returned improvements of 32.1%, 34.1% and 32.7%, respectively (p=0.0001 with respect to baseline). At 12 months, a statistically significant 62.2% of patients obtained an improvement equal to or greater than the MCII. The mean PGA score at baseline was 2.44 and 1.46 at 12 months (p With just a single intra-articular injection, this not controlled trial suggests that MPS-HA2% is effective 12 months after the procedure in most cases. Patient tolerability and safety were both optimal (NCT03852914).
SN 1178-7090
YR 2021
FD 2021-07-21
LK http://hdl.handle.net/10668/18271
UL http://hdl.handle.net/10668/18271
LA en
DS RISalud
RD Apr 6, 2025