RT Journal Article
T1 One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition.
A1 Vrieling, Alina
A1 Bueno-De-Mesquita, H Bas
A1 Ros, Martine M
A1 Kampman, Ellen
A1 Aben, Katja K
A1 Büchner, Frederike L
A1 Jansen, Eugène H
A1 Roswall, Nina
A1 Tjønneland, Anne
A1 Boutron-Ruault, Marie-Christine
A1 Cadeau, Claire
A1 Chang-Claude, Jenny
A1 Kaaks, Rudolf
A1 Weikert, Steffen
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Lagiou, Pagona
A1 Trichopoulos, Dimitrios
A1 Sieri, Sabina
A1 Palli, Domenico
A1 Panico, Salvatore
A1 Peeters, Petra H
A1 Weiderpass, Elisabete
A1 Skeie, Guri
A1 Jakszyn, Paula
A1 Chirlaque, María-Dolores
A1 Ardanaz, Eva
A1 Sanchez-Perez, Maria-Jose
A1 Ehrnström, Roy
A1 Malm, Johan
A1 Ljungberg, Börje
A1 Khaw, Kay-Tee
A1 Wareham, Nick J
A1 Brennan, Paul
A1 Johansson, Mattias
A1 Riboli, Elio
A1 Kiemeney, Lambertus A
K1 B-vitamins
K1 biomarker
K1 folate
K1 nested case-control
K1 urothelial cell carcinomas
AB Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case-control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824 cohort members. Serum folate, homocysteine, and vitamins B6 and B12 were measured. Odds ratios (OR) and 95% confidence intervals (CI) for total, aggressive, and non-aggressive UCC were estimated using conditional logistic regression with adjustment for smoking status, smoking duration and intensity, and other potential confounders. Additionally, statistical interaction with smoking status was assessed. A halving in serum folate concentrations was moderately associated with risk of UCC (OR: 1.18; 95% CI: 0.98-1.43), in particular aggressive UCC (OR: 1.34; 95% CI: 1.02-1.75; p-heterogeneity = 0.19). Compared to never smokers in the highest quartile of folate concentrations, this association seemed only apparent among current smokers in the lowest quartile of folate concentrations (OR: 6.26; 95% CI: 3.62-10.81, p-interaction = 0.07). Dietary folate was not associated with aggressive UCC (OR: 1.26; 95% CI: 0.81-1.95; p-heterogeneity = 0.14). No association was observed between serum homocysteine, vitamins B6 and B12 and risk of UCC. This study suggests that lower serum folate concentrations are associated with increased UCC risk, in particular aggressive UCC. Residual confounding by smoking cannot be ruled out and these findings require confirmation in future studies with multiple measurements.
YR 2019
FD 2019-02-13
LK http://hdl.handle.net/10668/13481
UL http://hdl.handle.net/10668/13481
LA en
DS RISalud
RD Apr 11, 2025