RT Journal Article
T1 Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review.
A1 Fernandez-Aparicio, Angel
A1 Correa-Rodriguez, Maria
A1 Castellano, Jose M
A1 Schmidt-RioValle, Jacqueline
A1 Perona, Javier S
A1 Gonzalez-Jimenez, Emilio
K1 Olea europaea
K1 bioactive compounds
K1 inflammation
K1 insulin resistance
K1 insulin signaling
K1 oleanolic acid
K1 oxidative stress
K1 pathways
K1 triterpenes
K1 type 2 diabetes mellitus
AB Oleanolic acid (OA) is a natural triterpene widely found in olive leaves that possesses antioxidant, anti-inflammatory, and insulin-sensitizing properties, among others. These OA characteristics could be of special interest in the treatment and prevention of insulin resistance (IR), but greater in-depth knowledge on the pathways involved in these properties is still needed. We aimed to systematically review the effects of OA on the molecular mechanisms and signaling pathways involved in the development of IR and underlying oxidative stress in insulin-resistant animal models or cell lines. The bibliographic search was carried out on PubMed, Web of Science, Scopus, Cochrane, and CINHAL databases between January 2001 and May 2022. The electronic search produced 5034 articles but, after applying the inclusion criteria, 13 animal studies and 3 cell experiments were identified, using SYRCLE's Risk of Bias for assessing the risk of bias of the animal studies. OA was found to enhance insulin sensitivity and glucose uptake, and was found to suppress the hepatic glucose production, probably by modulating the IRS/PI3K/Akt/FoxO1 signaling pathway and by mitigating oxidative stress through regulating MAPK pathways. Future randomized controlled clinical trials to assess the potential benefit of OA as new therapeutic and preventive strategies for IR are warranted.
PB MDPI AG
SN 2076-3921
YR 2022
FD 2022-08-03
LK http://hdl.handle.net/10668/20785
UL http://hdl.handle.net/10668/20785
LA en
NO Fernández-Aparicio Á, Correa-Rodríguez M, Castellano JM, Schmidt-RioValle J, Perona JS, González-Jiménez E. Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review. Antioxidants (Basel). 2022 Aug 3;11(8):1517.
DS RISalud
RD Apr 5, 2025