RT Journal Article
T1 Impact of Initial Antifungal Therapy on the Outcome of Patients With Candidemia and Septic Shock Admitted to Medical Wards: A Propensity Score-Adjusted Analysis.
A1 Falcone, Marco
A1 Tiseo, Giusy
A1 Gutiérrez-Gutiérrez, Belen
A1 Raponi, Giammarco
A1 Carfagna, Paolo
A1 Rosin, Chiara
A1 Luzzati, Roberto
A1 Delle Rose, Diego
A1 Andreoni, Massimo
A1 Farcomeni, Alessio
A1 Venditti, Mario
A1 Rodríguez-Baño, Jesus
A1 Menichetti, Francesco
A1 GISA (Italian Group for Antimicrobial Stewardship), 
K1 candidemia
K1 early antifungal therapy
K1 echinocandins
K1 septic shock
AB Echinocandins are recommended as firstline therapy in patients with candidemia. However, there is debate on their efficacy in survival outcomes. The aim of this study is to evaluate whether the choice of initial antifungal therapy improves mortality in patients with candidemia in relation to the presence of septic shock. Patients with candidemia hospitalized in internal medicine wards of 5 tertiary care centers were included in the study (December 2012-December 2014). Patient characteristics, therapeutic interventions, and outcome were reviewed. Propensity score (PS) was used as a covariate of the multivariate analysis to perform a stratified analysis according to PS quartiles and to match patients receiving "echinocandins" or "azoles." Overall, 439 patients with candidemia were included in the study. A total of 172 (39.2%) patients had septic shock. Thirty-day mortality was significantly higher in patients with septic shock (45.3%) compared with those without septic shock (31.5%; P = .003). Among patients with septic shock, the use of echinocandins in the first 48 hours, compared with azoles, did not affect 30-day mortality in the PS-adjusted Cox regression analysis (hazard ratio [HR], 0.77; 95% confidence interval [CI], 0.37-1.59; P = .48), the PS-stratified analysis, or the logistic regression model in matched cohorts (adjusted HR, 0.92; 95% CI, 0.51-1.63; P = .77). Echinocandin therapy seems not to improve the outcome of non-intensive care unit patients with septic shock due to candidemia. These findings support the urgent need of further studies in this patient population.
SN 2328-8957
YR 2019
FD 2019-07-16
LK https://hdl.handle.net/10668/27960
UL https://hdl.handle.net/10668/27960
LA en
DS RISalud
RD Apr 12, 2025