RT Journal Article
T1 Exosomes: Definition, Role in Tumor Development and Clinical Implications.
A1 Carretero-González, Alberto
A1 Otero, Irene
A1 Carril-Ajuria, Lucía
A1 de Velasco, Guillermo
A1 Manso, Luis
K1 Cancer
K1 Exosomes
K1 Metastasis
K1 Microenvironment
K1 Microvesicles
AB Exosomes are microvesicles released by cells in both physiological and pathological situations. They are surrounded by a lipid bilayer with proteins derived from the origin cell, and contain a variety of molecules, such as nucleic acids. They represent an emerging mechanism of intercellular communication, and they play an important role in the pathogenesis of cancer, stimulating proliferation and aggressiveness of cancer cells, inducing a microenvironment favorable to tumor development and controlling immune responses. Because of the growing understanding of the potential implications of extracellular vesicles in the development of malignancies, research on exosomes, and its role as a diagnostic and therapeutic tool, constitutes nowadays a very exciting and promising field.
SN 1875-2292
YR 2018
FD 2018-05-03
LK https://hdl.handle.net/10668/25335
UL https://hdl.handle.net/10668/25335
LA en
DS RISalud
RD Apr 12, 2025