RT Journal Article
T1 Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial.
A1 Hernáez, Álvaro
A1 Castañer, Olga
A1 Tresserra-Rimbau, Anna
A1 Pintó, Xavier
A1 Fitó, Montserrat
A1 Casas, Rosa
A1 Martínez-González, Miguel Ángel
A1 Corella, Dolores
A1 Salas-Salvadó, Jordi
A1 Lapetra, José
A1 Gómez-Gracia, Enrique
A1 Arós, Fernando
A1 Fiol, Miquel
A1 Serra-Majem, Lluis
A1 Ros, Emilio
A1 Estruch, Ramón
K1 Mediterranean diet
K1 atherothrombosis
K1 biomarkers
K1 cardiovascular risk
K1 clinical trials
AB To assess whether following a Mediterranean diet (MedDiet) improves atherothrombosis biomarkers in high cardiovascular risk individuals. In 358 random volunteers from the PREvención con DIeta MEDiterránea trial, the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO; n = 120) or nuts (MedDiet-Nuts; n = 119) versus a low-fat control diet (n = 119), and whether large increments in MedDiet adherence (≥3 score points, versus compliance decreases) and intake changes in key food items are associated with 1-year differences in biomarkers. Differences are observed between 1-year changes in the MedDiet-VOO intervention and control diet on the activity of platelet activating factor acetylhydrolase in high-density lipoproteins (HDLs) (+7.5% [95% confidence interval: 0.17; 14.8]) and HDL-bound α1 -antitrypsin levels (-6.1% [-11.8; -0.29]), and between the MedDiet-Nuts intervention and the control arm on non-esterified fatty acid concentrations (-9.3% [-18.1; -0.53]). Large MedDiet adherence increments are associated with less fibrinogen (-9.5% [-18.3; -0.60]) and non-esterified fatty acid concentrations (-16.7% [-31.7; -1.74]). Increases in nut, fruit, vegetable, and fatty fish consumption, and decreases in processed meat intake are linked to enhancements in biomarkers. MedDiet improves atherothrombosis biomarkers in high cardiovascular risk individuals.
YR 2020
FD 2020-09-30
LK http://hdl.handle.net/10668/16246
UL http://hdl.handle.net/10668/16246
LA en
DS RISalud
RD Apr 7, 2025