%0 Journal Article
%A Hernáez, Álvaro
%A Castañer, Olga
%A Tresserra-Rimbau, Anna
%A Pintó, Xavier
%A Fitó, Montserrat
%A Casas, Rosa
%A Martínez-González, Miguel Ángel
%A Corella, Dolores
%A Salas-Salvadó, Jordi
%A Lapetra, José
%A Gómez-Gracia, Enrique
%A Arós, Fernando
%A Fiol, Miquel
%A Serra-Majem, Lluis
%A Ros, Emilio
%A Estruch, Ramón
%T Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial.
%D 2020
%U http://hdl.handle.net/10668/16246
%X To assess whether following a Mediterranean diet (MedDiet) improves atherothrombosis biomarkers in high cardiovascular risk individuals. In 358 random volunteers from the PREvención con DIeta MEDiterránea trial, the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO; n = 120) or nuts (MedDiet-Nuts; n = 119) versus a low-fat control diet (n = 119), and whether large increments in MedDiet adherence (≥3 score points, versus compliance decreases) and intake changes in key food items are associated with 1-year differences in biomarkers. Differences are observed between 1-year changes in the MedDiet-VOO intervention and control diet on the activity of platelet activating factor acetylhydrolase in high-density lipoproteins (HDLs) (+7.5% [95% confidence interval: 0.17; 14.8]) and HDL-bound α1 -antitrypsin levels (-6.1% [-11.8; -0.29]), and between the MedDiet-Nuts intervention and the control arm on non-esterified fatty acid concentrations (-9.3% [-18.1; -0.53]). Large MedDiet adherence increments are associated with less fibrinogen (-9.5% [-18.3; -0.60]) and non-esterified fatty acid concentrations (-16.7% [-31.7; -1.74]). Increases in nut, fruit, vegetable, and fatty fish consumption, and decreases in processed meat intake are linked to enhancements in biomarkers. MedDiet improves atherothrombosis biomarkers in high cardiovascular risk individuals.
%K Mediterranean diet
%K atherothrombosis
%K biomarkers
%K cardiovascular risk
%K clinical trials
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