RT Journal Article
T1 Clinical Factors Associated with Reinfection versus Relapse in Infective Endocarditis: Prospective Cohort Study
A1 Calderon-Parra, Jorge
A1 Kestler, Martha
A1 Ramos-Martínez, Antonio
A1 Bouza, Emilio
A1 Valerio, Maricela
A1 de Alarcón, Arístides
A1 Luque, Rafael
A1 Goenaga, Miguel Ángel
A1 Echeverría, Tomás
A1 Fariñas, M. Carmen
A1 Pericàs, Juan M.
A1 Ojeda-Burgos, Guillermo
A1 Fernández-Cruz, Ana
A1 Plata, Antonio
A1 Vinuesa, David
A1 Muñoz, Patricia
K1 Endocarditis
K1 Recurrence
K1 Enterococcus
K1 Bacteremia
K1 Cardiac surgical procedures
K1 Liver disease
K1 Reinfection
AB We aimed to identify clinical factors associated with recurrent infective endocarditis (IE) episodes. The clinical characteristics of 2816 consecutive patients with definite IE (January 2008-2018) were compared according to the development of a second episode of IE. A total of 2152 out of 2282 (94.3%) patients, who were discharged alive and followed-up for at least the first year, presented a single episode of IE, whereas 130 patients (5.7%) presented a recurrence; 70 cases (53.8%) were due to other microorganisms (reinfection), and 60 cases (46.2%) were due to the same microorganism causing the first episode. Thirty-eight patients (29.2%), whose recurrence was due to the same microorganism, were diagnosed during the first 6 months of follow-up and were considered relapses. Relapses were associated with nosocomial endocarditis (OR: 2.67 (95% CI: 1.37-5.29)), enterococci (OR: 3.01 (95% CI: 1.51-6.01)), persistent bacteremia (OR: 2.37 (95% CI: 1.05-5.36)), and surgical treatment (OR: 0.23 (0.1-0.53)). On the other hand, episodes of reinfection were more common in patients with chronic liver disease (OR: 3.1 (95% CI: 1.65-5.83)) and prosthetic endocarditis (OR: 1.71 (95% CI: 1.04-2.82)). The clinical factors associated with reinfection and relapse in patients with IE appear to be different. A better understanding of these factors would allow the development of more effective therapeutic strategies.
PB MDPI
YR 2021
FD 2021-02-13
LK http://hdl.handle.net/10668/3900
UL http://hdl.handle.net/10668/3900
LA en
NO Calderón-Parra J, Kestler M, Ramos-Martínez A, Bouza E, Valerio M, de Alarcón A, et al. Clinical Factors Associated with Reinfection versus Relapse in Infective Endocarditis: Prospective Cohort Study. J Clin Med. 2021 Feb 13;10(4):748
DS RISalud
RD Apr 14, 2025