RT Journal Article
T1 Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?
A1 Johannessen, Ane
A1 Lønnebotn, Marianne
A1 Calciano, Lucia
A1 Benediktsdóttir, Bryndis
A1 Bertelsen, Randi Jacobsen
A1 Bråbäck, Lennart
A1 Dharmage, Shyamali
A1 Franklin, Karl A
A1 Gislason, Thorarinn
A1 Holm, Mathias
A1 Janson, Christer
A1 Jarvis, Deborah
A1 Jõgi, Rain
A1 Kim, Jeong-Lim
A1 Kirkeleit, Jorunn
A1 Lodge, Caroline
A1 Malinovschi, Andrei
A1 Martinez-Moratalla, Jesus
A1 Nilsen, Roy Miodini
A1 Pereira-Vega, Antonio
A1 Real, Francisco Gómez
A1 Schlünssen, Vivi
A1 Accordini, Simone
A1 Svanes, Cecilie
K1 Ageing Lungs in European Cohorts study
K1 epidemiology
K1 multilevel mediation model
K1 offspring
K1 parental risk factors
AB Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation. We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring. We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status. We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found. Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health.
YR 2019
FD 2019-09-07
LK http://hdl.handle.net/10668/14492
UL http://hdl.handle.net/10668/14492
LA en
DS RISalud
RD Apr 16, 2025