RT Journal Article
T1 Lupinus angustifolius Protein Hydrolysates Reduce Abdominal Adiposity and Ameliorate Metabolic Associated Fatty Liver Disease (MAFLD) in Western Diet Fed-ApoE-/- Mice.
A1 Santos-Sanchez, Guillermo
A1 Cruz-Chamorro, Ivan
A1 Alvarez-Rios, Ana Isabel
A1 Fernandez-Santos, Jose Maria
A1 Vazquez-Roman, Maria Victoria
A1 Rodriguez-Ortiz, Beatriz
A1 Alvarez-Sanchez, Nuria
A1 Alvarez-Lopez, Ana Isabel
A1 Millan-Linares, Maria Del Carmen
A1 Millan, Francisco
A1 Pedroche, Justo
A1 Fernandez-Pachon, Maria Soledad
A1 Lardone, Patricia Judith
A1 Guerrero, Juan Miguel
A1 Bejarano, Ignacio
A1 Carrillo-Vico, Antonio
K1 LDL
K1 NAFLD
K1 adipose tissue
K1 bioactive peptides
K1 cholesterol
K1 inflammation
K1 lupin
K1 oxidative stress
K1 steatosis
AB Metabolic-associated fatty liver disease (MAFLD) is the most important cause of liver disease worldwide. It is characterized by the accumulation of fat in the liver and is closely associated with abdominal obesity. In addition, oxidative stress and inflammation are significant features involved in MAFLD. Recently, our group demonstrated that lupin protein hydrolysates (LPHs) had lipid lowering, antioxidant, and anti-inflammatory effects. Sixty male mice fed with a Western diet were intragastrically treated with LPHs (or vehicle) for 12 weeks. Liver and adipose tissue lipid accumulation and hepatic inflammatory and oxidant status were evaluated. A significant decrease in steatosis was observed in LPHs-treated mice, which presented a decreased gene expression of CD36 and LDL-R, crucial markers in MAFLD. In addition, LPHs increased the hepatic total antioxidant capacity and reduced the hepatic inflammatory status. Moreover, LPHs-treated mice showed a significant reduction in abdominal adiposity. This is the first study to show that the supplementation with LPHs markedly ameliorates the generation of the steatotic liver caused by the intake of a Western diet and reduces abdominal obesity in ApoE-/- mice. Future clinical trials should shed light on the effects of LPHs on MAFLD.
PB MDPI AG
SN 2076-3921
YR 2021
FD 2021-07-29
LK http://hdl.handle.net/10668/18420
UL http://hdl.handle.net/10668/18420
LA en
NO Santos-Sánchez G, Cruz-Chamorro I, Álvarez-Ríos AI, Fernández-Santos JM, Vázquez-Román MV, Rodríguez-Ortiz B, et al. Lupinus angustifolius Protein Hydrolysates Reduce Abdominal Adiposity and Ameliorate Metabolic Associated Fatty Liver Disease (MAFLD) in Western Diet Fed-ApoE-/- Mice. Antioxidants (Basel). 2021 Jul 29;10(8):1222.
DS RISalud
RD Apr 17, 2025