RT Journal Article
T1 Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy.
A1 Firth, Nicholas C
A1 Primativo, Silvia
A1 Marinescu, Razvan-Valentin
A1 Shakespeare, Timothy J
A1 Suarez-Gonzalez, Aida
A1 Lehmann, Manja
A1 Carton, Amelia
A1 Ocal, Dilek
A1 Pavisic, Ivanna
A1 Paterson, Ross W
A1 Slattery, Catherine F
A1 Foulkes, Alexander J M
A1 Ridha, Basil H
A1 Gil-Néciga, Eulogio
A1 Oxtoby, Neil P
A1 Young, Alexandra L
A1 Modat, Marc
A1 Cardoso, M Jorge
A1 Ourselin, Sebastien
A1 Ryan, Natalie S
A1 Miller, Bruce L
A1 Rabinovici, Gil D
A1 Warrington, Elizabeth K
A1 Rossor, Martin N
A1 Fox, Nick C
A1 Warren, Jason D
A1 Alexander, Daniel C
A1 Schott, Jonathan M
A1 Yong, Keir X X
A1 Crutch, Sebastian J
K1 Alzheimer’s disease
K1 brain atrophy
K1 dementia
K1 memory
K1 structural MRI
AB Posterior cortical atrophy is a clinico-radiological syndrome characterized by progressive decline in visual processing and atrophy of posterior brain regions. With the majority of cases attributable to Alzheimer's disease and recent evidence for genetic risk factors specifically related to posterior cortical atrophy, the syndrome can provide important insights into selective vulnerability and phenotypic diversity. The present study describes the first major longitudinal investigation of posterior cortical atrophy disease progression. Three hundred and sixty-one individuals (117 posterior cortical atrophy, 106 typical Alzheimer's disease, 138 controls) fulfilling consensus criteria for posterior cortical atrophy-pure and typical Alzheimer's disease were recruited from three centres in the UK, Spain and USA. Participants underwent up to six annual assessments involving MRI scans and neuropsychological testing. We constructed longitudinal trajectories of regional brain volumes within posterior cortical atrophy and typical Alzheimer's disease using differential equation models. We compared and contrasted the order in which regional brain volumes become abnormal within posterior cortical atrophy and typical Alzheimer's disease using event-based models. We also examined trajectories of cognitive decline and the order in which different cognitive tests show abnormality using the same models. Temporally aligned trajectories for eight regions of interest revealed distinct (P
YR 2019
FD 2019
LK http://hdl.handle.net/10668/14149
UL http://hdl.handle.net/10668/14149
LA en
DS RISalud
RD Apr 7, 2025