RT Journal Article
T1 Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization.
A1 Dam, Veerle
A1 Onland-Moret, N Charlotte
A1 Burgess, Stephen
A1 Chirlaque, Maria-Dolores
A1 Peters, Sanne A E
A1 Schuit, Ewoud
A1 Tikk, Kaja
A1 Weiderpass, Elisabete
A1 Oliver-Williams, Clare
A1 Wood, Angela M
A1 Tjønneland, Anne
A1 Dahm, Christina C
A1 Overvad, Kim
A1 Boutron-Ruault, Marie-Christine
A1 Schulze, Matthias B
A1 Trichopoulou, Antonia
A1 Ferrari, Pietro
A1 Masala, Giovanna
A1 Krogh, Vittorio
A1 Tumino, Rosario
A1 Matullo, Giuseppe
A1 Panico, Salvatore
A1 Boer, Jolanda M A
A1 Verschuren, W M Monique
A1 Waaseth, Marit
A1 Pérez, Maria José Sánchez
A1 Amiano, Pilar
A1 Imaz, Liher
A1 Moreno-Iribas, Conchi
A1 Melander, Olle
A1 Harlid, Sophia
A1 Nordendahl, Maria
A1 Wennberg, Patrik
A1 Key, Timothy J
A1 Riboli, Elio
A1 Santiuste, Carmen
A1 Kaaks, Rudolf
A1 Katzke, Verena
A1 Langenberg, Claudia
A1 Wareham, Nicholas J
A1 Schunkert, Heribert
A1 Erdmann, Jeanette
A1 Willenborg, Christina
A1 Hengstenberg, Christian
A1 Kleber, Marcus E
A1 Delgado, Graciela
A1 März, Winfried
A1 Kanoni, Stavroula
A1 Dedoussis, George
A1 Deloukas, Panos
A1 Nikpay, Majid
A1 McPherson, Ruth
A1 Scholz, Markus
A1 Teren, Andrej
A1 Butterworth, Adam S
A1 van der Schouw, Yvonne T
K1 Mendelian Randomization
K1 coronary heart disease
K1 reproductive aging
K1 risk factors
AB Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause. To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in a bidirectional Mendelian randomization (MR) approach, using age at natural menopause (ANM) genetic variants as a measure for genetically determined reproductive aging in women. We also studied the association of these variants with CHD risk (factors) in men. Two-sample MR, using both cohort data as well as summary statistics, with 4 methods: simple and weighted median-based, standard inverse-variance weighted (IVW) regression, and MR-Egger regression. Data from EPIC-CVD and summary statistics from UK Biobank and publicly available genome-wide association studies were pooled for the different analyses. CHD, CHD risk factors, and ANM. Across different methods of MR, no association was found between genetically determined reproductive aging and CHD risk in women (relative risk estimateIVW = 0.99; 95% confidence interval (CI), 0.97-1.01), or any of the CHD risk factors. Similarly, no associations were found in men. Neither did the reversed analyses show evidence for an association between CHD (risk factors) and reproductive aging. Genetically determined reproductive aging is not causally associated with CHD risk (factors) in women, nor were the genetic variants associated in men. We found no evidence for a reverse association in a combined sample of women and men.
PB Oxford University Press
YR 2022
FD 2022-03-16
LK http://hdl.handle.net/10668/20394
UL http://hdl.handle.net/10668/20394
LA en
NO Dam V, Onland-Moret NC, Burgess S, Chirlaque MD, Peters SAE, Schuit E, et al. Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization. J Clin Endocrinol Metab. 2022 Jun 16;107(7):e2952-e2961.
DS RISalud
RD Apr 6, 2025