RT Journal Article
T1 TMS intensity and focality correlation with coil orientation at three non-motor regions.
A1 Gomez-Feria, Jose
A1 Fernandez-Corazza, Mariano
A1 Martin-Rodriguez, Juan F
A1 Mir, Pablo
K1 brain stimulation
K1 coil orientation
K1 computer simulation
K1 finite element analysis
K1 patient-specific modeling
K1 transcranial magnetic stimulation (TMS)
AB Objective. The aim of this study is to define the best coil orientations for transcranial magnetic stimulation (TMS) for three clinically relevant brain areas: pre-supplementary motor area (pre-SMA), inferior frontal gyrus (IFG), and posterior parietal cortex (PPC), by means of simulations in 12 realistic head models of the electric field (E-field).Methods. We computed the E-field generated by TMS in our three volumes of interest (VOI) that were delineated based on published atlases. We then analysed the maximum intensity and spatial focality for the normal and absolute components of the E-field considering different percentile thresholds. Lastly, we correlated these results with the different anatomical properties of our VOIs.Results. Overall, the spatial focality of the E-field for the three VOIs varied depending on the orientation of the coil. Further analysis showed that differences in individual brain anatomy were related to the amount of focality achieved. In general, a larger percentage of sulcus resulted in better spatial focality. Additionally, a higher normal E-field intensity was achieved when the coil axis was placed perpendicular to the predominant orientations of the gyri of each VOI. A positive correlation between spatial focality and E-field intensity was found for PPC and IFG but not for pre-SMA.Conclusions. For a rough approximation, better coil orientations can be based on the individual's specific brain morphology at the VOI. Moreover, TMS computational models should be employed to obtain better coil orientations in non-motor regions of interest.Significance. Finding better coil orientations in non-motor regions is a challenge in TMS and seeks to reduce interindividual variability. Our individualized TMS simulation pipeline leads to fewer inter-individual variability in the focality, likely enhancing the efficacy of the stimulation and reducing the risk of stimulating adjacent, non-targeted areas.
PB Institute of Physics Publishing Ltd.
YR 2022
FD 2022-02-21
LK http://hdl.handle.net/10668/19701
UL http://hdl.handle.net/10668/19701
LA en
NO Gomez-Feria J, Fernandez-Corazza M, Martin-Rodriguez JF, Mir P. TMS intensity and focality correlation with coil orientation at three non-motor regions. Phys Med Biol. 2022 Feb 21;67(5).
DS RISalud
RD Jul 30, 2025