RT Journal Article
T1 The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment
A1 Peter, Jessica
A1 Mayer, Isabella
A1 Kammer, Thomas
A1 Minkova, Lora
A1 Lahr, Jacob
A1 Klöppel, Stefan
A1 Grothe, Michel J.
A1 Orth, Michael
K1 Healthy volunteers
K1 Basal forebrain
K1 Thalamus
K1 Cognitive dysfunction
K1 Voluntarios sanos
K1 Prosencéfalo basal
K1 Tálamo
K1 Disfunción Cognitiva
AB We assessed the structure–function relationship of the human cholinergic system and hypothesized that structural measures are associated with short-latency sensory afferent inhibition (SAI), an electrophysiological measure of central cholinergic signal transmission. Healthy volunteers (n = 36) and patients with mild cognitive impairment (MCI, n = 20) underwent median nerve SAI and 3T structural MRI to determine the volume of the basal forebrain and the thalamus. Patients with MCI had smaller basal forebrain (p < 0.001) or thalamus volumes (p < 0.001) than healthy volunteers. Healthy SAI responders (> 10% SAI) had more basal forebrain volume than non-responders (p = 0.004) or patients with MCI (p < 0.001). More basal forebrain volume was associated with stronger SAI in healthy volunteers (r = 0.33, p < 0.05) but not patients with MCI. There was no significant relationship between thalamus volumes and SAI. Basal forebrain volume is associated with cholinergic function (SAI) in healthy volunteers but not in MCI patients. The in-vivo investigation of the structure–function relationship could further our understanding of the human cholinergic system in patients with suspected or known cholinergic system degeneration.
PB Springer Nature
YR 2021
FD 2021-08-09
LK http://hdl.handle.net/10668/4541
UL http://hdl.handle.net/10668/4541
LA en
NO Peter J, Mayer I, Kammer T, Minkova L, Lahr J, Klöppel S, et al. The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment. Sci Rep. 2021 Aug 9;11(1):16080
DS RISalud
RD Apr 6, 2025