RT Journal Article
T1 Clinical and Ultrasound Thyroid Nodule Characteristics and Their Association with Cytological and Histopathological Outcomes: A Retrospective Multicenter Study in High-Resolution Thyroid Nodule Clinics.
A1 Molina-Vega, Maria
A1 Rodriguez-Perez, Carlos Antonio
A1 Alvarez-Mancha, Ana Isabel
A1 Baena-Nieto, Gloria
A1 Riestra, Maria
A1 Alcazar, Victoria
A1 Romero-Lluch, Ana Reyes
A1 Galofre, Juan C
A1 Fernandez-Garcia, Jose C
K1 fine needle aspiration
K1 thyroid nodules
K1 ultrasound
AB Thyroid nodules are a common finding. A high-resolution thyroid nodule clinic (HR-TNC) condenses all tests required for the evaluation of thyroid nodules into a single appointment. We aimed to evaluate the clinical outcomes at HR-TNCs. A retrospective cross-sectional multicenter study including data from four HR-TNCs in Spain. We evaluated fine-needle aspiration (FNA) indications and the association between clinical and ultrasound characteristics with cytological and histopathological outcomes. A total of 2809 thyroid nodules were included; FNA was performed in 82.1%. Thyroid nodules that underwent FNA were more likely larger, isoechoic, with microcalcifications, and in younger subjects. The rate of nondiagnostic FNA was 4.3%. A solid component, irregular margins or microcalcifications, significantly increased the odds of Bethesda IV-V-VI (vs. Bethesda II). Irregular margins and a solid component were independently associated with increased odds of malignancy. Thyroid nodules  In this large multicenter study, we found that the presence of a solid component and irregular margins are factors independently related to malignancy in thyroid nodules. Since nodule size ≥40 mm was associated with the lowest odds of malignancy, this cut-off should not be a factor leading to indicate thyroid surgery. HR-TNCs were associated with a low rate of nondiagnostic FNA.
PB MDPI AG
SN 2077-0383
YR 2019
FD 2019-12-09
LK https://hdl.handle.net/10668/27789
UL https://hdl.handle.net/10668/27789
LA en
NO Molina-Vega M, Rodríguez-Pérez CA, Álvarez-Mancha AI, Baena-Nieto G, Riestra M, Alcázar V, et al. Clinical and Ultrasound Thyroid Nodule Characteristics and Their Association with Cytological and Histopathological Outcomes: A Retrospective Multicenter Study in High-Resolution Thyroid Nodule Clinics. J Clin Med. 2019 Dec 9;8(12):2172.
DS RISalud
RD Sep 19, 2025