RT Journal Article
T1 Downregulated microRNAs in the colorectal cancer: diagnostic and therapeutic perspectives.
A1 Hernandez, Rosa
A1 Sanchez-Jimenez, Ester
A1 Melguizo, Consolacion
A1 Prados, Jose
A1 Rama, Ana Rosa
K1 Biomarkers
K1 Colorectal cancer
K1 Diagnosis
K1 miRNA
K1 Therapeutic target
AB Colorectal cancer (CRC), the third most common cancer in the world, has no specific biomarkers that facilitate its diagnosis and subsequent treatment. The miRNAs, small single-stranded RNAs that repress the mRNA translation and trigger the mRNA degradation, show aberrant levels in the CRC, by which these molecules have been related with the initiation, progression, and drug-resistance of this cancer type. Numerous studies show the microRNAs influence the cellular mechanisms related to the cell cycle, differentiation, apoptosis, and migration of the cancer cells through the post-transcriptionally regulated gene expression. Specific patterns of the upregulated and down-regulated miRNA have been associated with the CRC diagnosis, prognosis, and therapeutic response. Concretely, the downregulated miRNAs represent attractive candidates, not only for the CRC diagnosis, but for the targeted therapies via the tumor-suppressing microRNA replacement. This review shows a general overview of the potential uses of the miRNAs in the CRC diagnosis, prognosis, and treatment with a special focus on the downregulated ones. [BMB Reports 2018; 51(11): 563-571].
PB Korean Society for Biochemistry and Molecular Biology
YR 2018
FD 2018-07-10
LK http://hdl.handle.net/10668/12882
UL http://hdl.handle.net/10668/12882
LA en
NO Hernández R, Sánchez-Jiménez E, Melguizo C, Prados J, Rama AR. Downregulated microRNAs in the colorectal cancer: diagnostic and therapeutic perspectives. BMB Rep. 2018 Nov;51(11):563-571.
NO This review was funded by Consejería de Salud de la Junta de Andalucía through the project PI-0476-2016, Granada University project PP2015-13, and the financial groups 09/112016. We thank Ministerio de Educacion Cultura y Deporte for its research grant (FPU).
DS RISalud
RD Apr 11, 2025