RT Journal Article
T1 A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
A1 Jhun, Min-A
A1 Mendelson, Michael
A1 Wilson, Rory
A1 Gondalia, Rahul
A1 Joehanes, Roby
A1 Salfati, Elias
A1 Zhao, Xiaoping
A1 Braun, Kim Valeska Emilie
A1 Do, Anh Nguyet
A1 Hedman, Åsa K
A1 Zhang, Tao
A1 Carnero-Montoro, Elena
A1 Shen, Jincheng
A1 Bartz, Traci M
A1 Brody, Jennifer A
A1 Montasser, May E
A1 O'Connell, Jeff R
A1 Yao, Chen
A1 Xia, Rui
A1 Boerwinkle, Eric
A1 Grove, Megan
A1 Guan, Weihua
A1 Liliane, Pfeiffer
A1 Singmann, Paula
A1 Müller-Nurasyid, Martina
A1 Meitinger, Thomas
A1 Gieger, Christian
A1 Peters, Annette
A1 Zhao, Wei
A1 Ware, Erin B
A1 Smith, Jennifer A
A1 Dhana, Klodian
A1 van Meurs, Joyce
A1 Uitterlinden, Andre
A1 Ikram, Mohammad Arfan
A1 Ghanbari, Mohsen
A1 Zhi, Deugi
A1 Gustafsson, Stefan
A1 Lind, Lars
A1 Li, Shengxu
A1 Sun, Dianjianyi
A1 Spector, Tim D
A1 Chen, Yii-der Ida
A1 Damcott, Coleen
A1 Shuldiner, Alan R
A1 Absher, Devin M
A1 Horvath, Steve
A1 Tsao, Philip S
A1 Kardia, Sharon
A1 Psaty, Bruce M
A1 Sotoodehnia, Nona
A1 Bell, Jordana T
A1 Ingelsson, Erik
A1 Chen, Wei
A1 Dehghan, Abbas
A1 Arnett, Donna K
A1 Waldenberger, Melanie
A1 Hou, Lifang
A1 Whitsel, Eric A
A1 Baccarelli, Andrea
A1 Levy, Daniel
A1 Fornage, Myriam
A1 Irvin, Marguerite R
A1 Assimes, Themistocles L
AB Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups.
YR 2021
FD 2021-06-28
LK http://hdl.handle.net/10668/18053
UL http://hdl.handle.net/10668/18053
LA en
DS RISalud
RD Apr 7, 2025