RT Journal Article
T1 Cognitive Performance and Health-Related Quality of Life in Patients with Neuromyelitis Optica Spectrum Disorder.
A1 Lopez-Soley, Elisabet
A1 Meca-Lallana, Jose E
A1 Llufriu, Sara
A1 Blanco, Yolanda
A1 Gómez-Ballesteros, Rocío
A1 Maurino, Jorge
A1 Pérez-Miralles, Francisco
A1 Forero, Lucía
A1 Calles, Carmen
A1 Martinez-Gines, María L
A1 Gonzalez-Suarez, Inés
A1 Boyero, Sabas
A1 Romero-Pinel, Lucía
A1 Sempere, Ángel P
A1 Meca-Lallana, Virginia
A1 Querol, Luis
A1 Costa-Frossard, Lucienne
A1 Sepulveda, Maria
A1 Solana, Elisabeth
K1 cognition
K1 health-related quality of life
K1 mood
K1 neuromyelitis optica spectrum disorder
AB Background: The frequency of cognitive impairment (CI) reported in neuromyelitis optica spectrum disorder (NMOSD) is highly variable, and its relationship with demographic and clinical characteristics is poorly understood. We aimed to describe the cognitive profile of NMOSD patients, and to analyse the cognitive differences according to their serostatus; furthermore, we aimed to assess the relationship between cognition, demographic and clinical characteristics, and other aspects linked to health-related quality of life (HRQoL). Methods: This cross-sectional study included 41 patients (median age, 44 years; 85% women) from 13 Spanish centres. Demographic and clinical characteristics were collected along with a cognitive z-score (Rao’s Battery) and HRQoL patient-centred measures, and their relationship was explored using linear regression. We used the Akaike information criterion to model which characteristics were associated with cognition. Results: Fourteen patients (34%) had CI, and the most affected cognitive domain was visual memory. Cognition was similar in AQP4-IgG-positive and -negative patients. Gender, mood, fatigue, satisfaction with life, and perception of stigma were associated with cognitive performance (adjusted R2 = 0.396, p
SN 2075-4426
YR 2022
FD 2022-05-02
LK http://hdl.handle.net/10668/21378
UL http://hdl.handle.net/10668/21378
LA en
DS RISalud
RD Apr 19, 2025