%0 Journal Article
%A Buell-Acosta, Julieth Daniela
%A Garces, Maria Fernanda
%A Parada-Baños, Arturo Jose
%A Angel-Muller, Edith
%A Paez, Maria Carolina
%A Eslava-Schmalbach, Javier
%A Escobar-Cordoba, Franklin
%A Caminos-Cepeda, Sofia Alexandra
%A Lacunza, Ezequiel
%A Castaño, Justo P
%A Nogueiras, Ruben
%A Dieguez, Carlos
%A Ruiz-Parra, Ariel Ivan
%A Caminos, Jorge Eduardo
%T Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women-A Longitudinal Study.
%D 2022
%U http://hdl.handle.net/10668/20933
%X (1) Background: Fibroblast growth factor 21 (FGF-21) is an endocrine factor involved in glucose and lipid metabolism that exerts pleiotropic effects. The aim of this study was to investigate the serum FGF-21 profile in healthy and mild preeclamptic pregnant women at each trimester of pregnancy; (2) Methods: Serum FGF-21 levels were determined by ELISA in a nested case-control study within a longitudinal cohort study that included healthy (n = 54) and mild preeclamptic (n = 20) pregnant women, women at three months after delivery (n = 20) and eumenorrheic women during the menstrual cycle (n = 20); (3) Results: FGF-21 levels were significantly lower in the mid-luteal phase compared to the early follicular phase of the menstrual cycle in eumenorrheic women (p< 0.01). Maternal levels of FGF-21 were significantly lower in the first and second trimesters and peaked during the third trimester in healthy pregnant women (p < 0.01). Serum levels of FGF-21 in healthypregnant were significantly lower in the first and second trimester of pregnancy compared with the follicular phase of the menstrual cycle and postpartum (p < 0.01). Serum FGF-21 levels were significantly higher in preeclamptic compared to healthy pregnant women during pregnancy (p < 0.01); (4) Conclusions: These results suggest that a peak of FGF-21 towards the end of pregnancy in healthy pregnancy and higher levels in preeclamptic women might play a critical role that contributes to protecting against the negatives effects of high concentrations of non-esterified fatty acids (NEFA) and hypertensive disorder. Furthermore, FGF-21 might play an important role in reproductive function in healthy eumenorrheic women during the menstrual cycle.
%K FGF-21
%K Menstrual cycle
%K Preeclampsia
%K Pregnancy
%~