RT Journal Article
T1 OXA-48 Carbapenemase-Producing Enterobacterales in Spanish Hospitals: An Updated Comprehensive Review on a Rising Antimicrobial Resistance.
A1 Rivera-Izquierdo, Mario
A1 Láinez-Ramos-Bossini, Antonio Jesús
A1 Rivera-Izquierdo, Carlos
A1 López-Gómez, Jairo
A1 Fernández-Martínez, Nicolás Francisco
A1 Redruello-Guerrero, Pablo
A1 Martín-delosReyes, Luis Miguel
A1 Martínez-Ruiz, Virginia
A1 Moreno-Roldán, Elena
A1 Jiménez-Mejías, Eladio
K1 OXA-48
K1 Spain
K1 antibiotic stewardship
K1 carbapenem
K1 carbapenemase
K1 enterobacteria
K1 multiresistant
K1 outbreak
AB Carbapenemase-producing Enterobacterales (CPE) are significant contributors to the global public health threat of antimicrobial resistance. OXA-48-like enzymes and their variants are unique carbapenemases with low or null hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins. CPEs have been classified by the WHO as high-priority pathogens given their association with morbidity and mortality and the scarce number of effective antibiotic treatments. In Spain, the frequency of OXA-48 CPE outbreaks is higher than in other European countries, representing the major resistance mechanism of CPEs. Horizontal transfer of plasmids and poor effective antibiotic treatment are additional threats to the correct prevention and control of these hospital outbreaks. One of the most important risk factors is antibiotic pressure, specifically carbapenem overuse. We explored the use of these antibiotics in Spain and analyzed the frequency, characteristics and prevention of CPE outbreaks. Future antibiotic stewardship programs along with specific preventive measures in hospitalized patients must be reinforced and updated in Spain.
SN 2079-6382
YR 2021
FD 2021-01-18
LK https://hdl.handle.net/10668/28326
UL https://hdl.handle.net/10668/28326
LA en
DS RISalud
RD Apr 17, 2025