RT Journal Article
T1 Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years.
A1 Frangou, Sophia
A1 Modabbernia, Amirhossein
A1 Williams, Steven C R
A1 Papachristou, Efstathios
A1 Doucet, Gaelle E
A1 Agartz, Ingrid
A1 Aghajani, Moji
A1 Akudjedu, Theophilus N
A1 Albajes-Eizagirre, Anton
A1 Alnaes, Dag
A1 Alpert, Kathryn I
A1 Andersson, Micael
A1 Andreasen, Nancy C
A1 Andreassen, Ole A
A1 Asherson, Philip
A1 Banaschewski, Tobias
A1 Bargallo, Nuria
A1 Baumeister, Sarah
A1 Baur-Streubel, Ramona
A1 Bertolino, Alessandro
A1 Bonvino, Aurora
A1 Boomsma, Dorret I
A1 Borgwardt, Stefan
A1 Bourque, Josiane
A1 Brandeis, Daniel
A1 Breier, Alan
A1 Brodaty, Henry
A1 Brouwer, Rachel M
A1 Buitelaar, Jan K
A1 Busatto, Geraldo F
A1 Buckner, Randy L
A1 Calhoun, Vincent
A1 Canales-Rodríguez, Erick J
A1 Cannon, Dara M
A1 Caseras, Xavier
A1 Castellanos, Francisco X
A1 Cervenka, Simon
A1 Chaim-Avancini, Tiffany M
A1 Ching, Christopher R K
A1 Chubar, Victoria
A1 Clark, Vincent P
A1 Conrod, Patricia
A1 Conzelmann, Annette
A1 Crespo-Facorro, Benedicto
A1 Crivello, Fabrice
A1 Crone, Eveline A
A1 Dale, Anders M
A1 Dannlowski, Udo
A1 Davey, Christopher
A1 de Geus, Eco J C
A1 de Haan, Lieuwe
A1 de Zubicaray, Greig I
A1 den Braber, Anouk
A1 Dickie, Erin W
A1 Di Giorgio, Annabella
A1 Doan, Nhat Trung
A1 Dørum, Erlend S
A1 Ehrlich, Stefan
A1 Erk, Susanne
A1 Espeseth, Thomas
A1 Fatouros-Bergman, Helena
A1 Fisher, Simon E
A1 Fouche, Jean-Paul
A1 Franke, Barbara
A1 Frodl, Thomas
A1 Fuentes-Claramonte, Paola
A1 Glahn, David C
A1 Gotlib, Ian H
A1 Grabe, Hans-Jörgen
A1 Grimm, Oliver
A1 Groenewold, Nynke A
A1 Grotegerd, Dominik
A1 Gruber, Oliver
A1 Gruner, Patricia
A1 Gur, Rachel E
A1 Gur, Ruben C
A1 Hahn, Tim
A1 Harrison, Ben J
A1 Hartman, Catharine A
A1 Hatton, Sean N
A1 Heinz, Andreas
A1 Heslenfeld, Dirk J
A1 Hibar, Derrek P
A1 Hickie, Ian B
A1 Ho, Beng-Choon
A1 Hoekstra, Pieter J
A1 Hohmann, Sarah
A1 Holmes, Avram J
A1 Hoogman, Martine
A1 Hosten, Norbert
A1 Howells, Fleur M
A1 Hulshoff Pol, Hilleke E
A1 Huyser, Chaim
A1 Jahanshad, Neda
A1 James, Anthony
A1 Jernigan, Terry L
A1 Jiang, Jiyang
A1 Jönsson, Erik G
A1 Joska, John A
A1 Kahn, Rene
A1 Kalnin, Andrew
A1 Kanai, Ryota
A1 Klein, Marieke
A1 Klyushnik, Tatyana P
A1 Koenders, Laura
A1 Koops, Sanne
A1 Krämer, Bernd
A1 Kuntsi, Jonna
A1 Lagopoulos, Jim
A1 Lázaro, Luisa
A1 Lebedeva, Irina
A1 Lee, Won Hee
A1 Lesch, Klaus-Peter
A1 Lochner, Christine
A1 Machielsen, Marise W J
A1 Maingault, Sophie
A1 Martin, Nicholas G
A1 Martínez-Zalacaín, Ignacio
A1 Mataix-Cols, David
A1 Mazoyer, Bernard
A1 McDonald, Colm
A1 McDonald, Brenna C
A1 McIntosh, Andrew M
A1 McMahon, Katie L
A1 McPhilemy, Genevieve
A1 Meinert, Susanne
A1 Menchón, José M
A1 Medland, Sarah E
A1 Meyer-Lindenberg, Andreas
A1 Naaijen, Jilly
A1 Najt, Pablo
A1 Nakao, Tomohiro
A1 Nordvik, Jan E
A1 Nyberg, Lars
A1 Oosterlaan, Jaap
A1 de la Foz, Víctor Ortiz-García
A1 Paloyelis, Yannis
A1 Pauli, Paul
A1 Pergola, Giulio
A1 Pomarol-Clotet, Edith
A1 Portella, Maria J
A1 Potkin, Steven G
A1 Radua, Joaquim
A1 Reif, Andreas
A1 Rinker, Daniel A
A1 Roffman, Joshua L
A1 Rosa, Pedro G P
A1 Sacchet, Matthew D
A1 Sachdev, Perminder S
A1 Salvador, Raymond
A1 Sánchez-Juan, Pascual
A1 Sarró, Salvador
A1 Satterthwaite, Theodore D
A1 Saykin, Andrew J
A1 Serpa, Mauricio H
A1 Schmaal, Lianne
A1 Schnell, Knut
A1 Schumann, Gunter
A1 Sim, Kang
A1 Smoller, Jordan W
A1 Sommer, Iris
A1 Soriano-Mas, Carles
A1 Stein, Dan J
A1 Strike, Lachlan T
A1 Swagerman, Suzanne C
A1 Tamnes, Christian K
A1 Temmingh, Henk S
A1 Thomopoulos, Sophia I
A1 Tomyshev, Alexander S
A1 Tordesillas-Gutiérrez, Diana
A1 Trollor, Julian N
A1 Turner, Jessica A
A1 Uhlmann, Anne
A1 van den Heuvel, Odile A
A1 van den Meer, Dennis
A1 van der Wee, Nic J A
A1 van Haren, Neeltje E M
A1 van 't Ent, Dennis
A1 van Erp, Theo G M
A1 Veer, Ilya M
A1 Veltman, Dick J
A1 Voineskos, Aristotle
A1 Völzke, Henry
A1 Walter, Henrik
A1 Walton, Esther
A1 Wang, Lei
A1 Wang, Yang
A1 Wassink, Thomas H
A1 Weber, Bernd
A1 Wen, Wei
A1 West, John D
A1 Westlye, Lars T
A1 Whalley, Heather
A1 Wierenga, Lara M
A1 Wittfeld, Katharina
A1 Wolf, Daniel H
A1 Worker, Amanda
A1 Wright, Margaret J
A1 Yang, Kun
A1 Yoncheva, Yulyia
A1 Zanetti, Marcus V
A1 Ziegler, Georg C
A1 Karolinska Schizophrenia Project (KaSP), 
A1 Thompson, Paul M
A1 Dima, Danai
K1 aging
K1 cortical thickness
K1 development
K1 trajectories
AB Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
YR 2021
FD 2021-02-17
LK http://hdl.handle.net/10668/17192
UL http://hdl.handle.net/10668/17192
LA en
DS RISalud
RD Apr 8, 2025