RT Journal Article
T1 Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study.
A1 Barrubés, Laura
A1 Babio, Nancy
A1 Hernández-Alonso, Pablo
A1 Toledo, Estefania
A1 Ramírez Sabio, Judith B
A1 Estruch, Ramón
A1 Ros, Emilio
A1 Fitó, Montserrat
A1 Alonso-Gómez, Angel M
A1 Fiol, Miquel
A1 Lapetra, Jose
A1 Serra-Majem, Lluís
A1 Pintó, Xavier
A1 Ruiz-Canela, Miguel
A1 Corella, Dolores
A1 Castañer, Olga
A1 Macías-González, Manuel
A1 Salas-Salvadó, Jordi
K1 PREDIMED
K1 WCRF/AICR score
K1 colorectal cancer
K1 lifestyle patterns
K1 low-risk lifestyle index
AB Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other global lifestyle indices, and none in aged populations at high cardiovascular risk. We aimed to assess the association between CRC incidence and adherence to two emerging lifestyles indices (2018 WCRF/AICR score and another low-risk lifestyle (LRL) score comprising smoking status, alcohol consumption, physical activity, diet, and body mass index) in the Spanish PREvencion con DIeta MEDiterranea (PREDIMED) cohort. We studied 7216 elderly men and women at high cardiovascular risk. The 2018 WCRF/AICR and LRL scores were calculated. Multivariable Cox proportional regression models were fitted to estimate the HRs (hazard ratios) and 95% confidence intervals (CIs) for incident CRC events. During a median interquartile range (IQR) follow-up of 6.0 (4.4-7.3) years, 97 CRC events were considered. A significant linear association was observed between each 1-point increment in the WCRF/AICR score (score range from 0 to 7) and CRC risk (HR (95% CI) = 0.79 (0.63-0.99)). Similarly, each 1-point increment in the LRL score (score range from 0 to 5) was associated with a 22% reduction in CRC risk (0.78 (0.64-0.96)). Adhering to emergent lifestyle scores might substantially reduce CRC incidence in elderly individuals. Further longitudinal studies, which take different lifestyle indexes into account, are warranted in the future.
SN 2077-0383
YR 2020
FD 2020-04-23
LK https://hdl.handle.net/10668/26645
UL https://hdl.handle.net/10668/26645
LA en
DS RISalud
RD Apr 5, 2025