RT Journal Article
T1 Dairy consumption, plasma metabolites, and risk of type 2 diabetes.
A1 Drouin-Chartier, Jean-Philippe
A1 Hernández-Alonso, Pablo
A1 Guasch-Ferré, Marta
A1 Ruiz-Canela, Miguel
A1 Li, Jun
A1 Wittenbecher, Clemens
A1 Razquin, Cristina
A1 Toledo, Estefanía
A1 Dennis, Courtney
A1 Corella, Dolores
A1 Estruch, Ramon
A1 Fitó, Montserrat
A1 Eliassen, A Heather
A1 Tobias, Deirdre K
A1 Ascherio, Alberto
A1 Mucci, Lorelei A
A1 Rexrode, Kathryn M
A1 Karlson, Elizabeth W
A1 Costenbader, Karen H
A1 Fuchs, Charles S
A1 Liang, Liming
A1 Clish, Clary B
A1 Martínez-González, Miguel A
A1 Salas-Salvadó, Jordi
A1 Hu, Frank B
K1 cheese
K1 dairy
K1 metabolomics
K1 milk
K1 prospective cohort study
K1 type 2 diabetes
K1 yogurt
AB Epidemiologic studies have reported a modest inverse association between dairy consumption and the risk of type 2 diabetes (T2D). Whether plasma metabolite profiles associated with dairy consumption reflect this relationship remains unknown. We aimed to identify the plasma metabolites associated with total and specific dairy consumption, and to evaluate the association between the identified multi-metabolite profiles and T2D. The discovery population included 1833 participants from the Prevención con Dieta Mediterránea (PREDIMED) trial. The confirmatory cohorts included 1522 PREDIMED participants at year 1 of the trial and 4932 participants from the Nurses' Health Studies (NHS), Nurses' Health Study II (NHSII), and Health Professionals Follow-Up Study US-based cohorts. Dairy consumption was assessed using validated FFQs. Plasma metabolites (n = 385) were profiled using LC-MS. We identified the dairy-related metabolite profiles using elastic net regularized regressions with a 10-fold cross-validation procedure. We evaluated the associations between the metabolite profiles and incident T2D in the discovery and the confirmatory cohorts. Total dairy intake was associated with 38 metabolites. C14:0 sphingomyelin (positive coefficient), C34:0 phosphatidylethanolamine (positive coefficient), and γ-butyrobetaine (negative coefficient) were associated in a directionally similar fashion with total and specific (milk, yogurt, cheese) dairy consumption. The Pearson correlation coefficients between self-reported total dairy intake and predicted total dairy intake based on the corresponding multi-metabolite profile were 0.37 (95% CI, 0.33-0.40) in the discovery cohort and 0.16 (95% CI, 0.13-0.19) in the US confirmatory cohort. After adjusting for T2D risk factors, a higher total dairy intake-related metabolite profile score was associated with a lower T2D risk [HR per 1 SD; discovery cohort: 0.76 (95% CI, 0.63-0.90); US confirmatory cohort: 0.88 (95% CI, 0.78-0.99)]. Total dairy intake was associated with 38 metabolites, including 3 consistently associated with dairy subtypes (C14:0 sphingomyelin, C34:0 phosphatidylethanolamine, γ-butyrobetaine). A score based on the 38 identified metabolites showed an inverse association with T2D risk in Spanish and US populations.
YR 2021
FD 2021
LK http://hdl.handle.net/10668/17372
UL http://hdl.handle.net/10668/17372
LA en
DS RISalud
RD Apr 14, 2025