RT Journal Article
T1 Antecedentes familiares de primer grado como factor de riesgo en el cáncer colorrectal.
T2 [Family history of first degree as a risk factor for colorectal cancer]
A1 Rubin-Garcia, Maria
A1 Martin, Vicente
A1 Vitelli-Storelli, Facundo
A1 Moreno, Victor
A1 Aragones, Nuria
A1 Ardanaz, Eva
A1 Alonso-Molero, Jessica
A1 Jimenez-Moleon, Jose J
A1 Amiano, Pilar
A1 Fernandez-Tardon, Guillermo
A1 Molina-Barcelo, Ana
A1 Alguacil, Juan
A1 Dolores-Chirlaque, María
A1 Alvarez-Alvarez, Laura
A1 Perez-Gomez, Beatriz
A1 Dierssen-Sotos, Trinidad
A1 Olmedo-Requena, Rocio
A1 Guevara, Marcela
A1 Fernandez-Villa, Tania
A1 Pollan, Marina
A1 Benavente, Yolanda
K1 Antecedentes familiares
K1 Case and control
K1 Casos y controles
K1 Colorectal cancer
K1 Cáncer colorrectal
K1 Factor de riesgo
K1 Family history
K1 MCC-Spain
K1 Risk factor
AB To evaluate the association between first-degree family history and colorectal cancer (CRC). We analyzed data from 2857 controls and 1360 CRC cases, collected in the MCC-Spain project. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) of association with the family history of CRC was estimated by non-conditional logistic regression. First-degree relatives doubled the risk of CRC (OR: 2.19; 95% CI: 1.80-2.66), increasing in those with two or more (OR: 4.22; 95% CI: 2.29-7.78) and in those whose relatives were diagnosed before 50 years (OR: 3.24; 95% CI: 1.52-6.91). Regarding the association of the family history with the location, no significant differences were observed between colon and rectum, but there were in the relation of these with the age of diagnosis, having more relatives those diagnosed before 50 years (OR: 4.79; 95% CI: 2.65-8.65). First-degree relatives of CRC increase the chances of developing this tumor, they also increase when the relative is diagnosed at an early age. Therefore, it must be a target population on which to carry out prevention measures.
PB Elsevier Doyma
YR 2021
FD 2021-04-23
LK http://hdl.handle.net/10668/22237
UL http://hdl.handle.net/10668/22237
LA es
NO Rubín-García M, Martín V, Vitelli-Storelli F, Moreno V, Aragonés N, Ardanaz E,  et al. Antecedentes familiares de primer grado como factor de riesgo en el cáncer colorrectal [Family history of first degree as a risk factor for colorectal cancer]. Gac Sanit. 2022 Jul-Aug;36(4):345-352.
DS RISalud
RD Apr 5, 2025