%0 Journal Article
%A Hernandez-Martinez, Alvaro
%A Navajas-Hernandez, Pilar
%A Martin-Rodriguez, Maria Del Mar
%A Lazaro-Saez, Marta
%A Olmedo-Martin, Raul
%A Nuñez-Ortiz, Andrea
%A Argüelles-Arias, Federico
%A Fernandez Cano, Maria Carmen
%A Gallardo-Sanchez, Francisco
%A Marin-Pedrosa, Sandra
%A Gonzalez-Garcia, Javier
%A Vazquez-Moron, Juan Maria
%T Efficacy and safety of tofacitinib in the treatment of ulcerative colitis: real-life experience in Andalusia.
%D 2021
%@ 1130-0108
%U http://hdl.handle.net/10668/21721
%X Tofacitinib is a Janus kinase inhibitor approved for the treatment of moderate-severe ulcerative colitis (UC). This study aimed to evaluate its efficacy in a real-life setting. a retrospective and multicenter observational study was performed with UC patients treated with tofacitinib. Short and long-term treatment effectiveness, treatment survival, need for dose escalation and safety were analyzed. Clinical response and remission were defined in accordance with the partial Mayo score. seventy-four patients were included, 98.3 % had received prior biological treatment, 55.4 % with three or more biologicals and up to 64.9% with two or three different mechanisms of action. Clinical remission and response rates were 37.8 % and 77 % at eight weeks, and 41.8 % and 70.1 % at 16 weeks. With regard to non-responders at eight weeks, 37.5 % achieved a delayed clinical response at 16 weeks. Mean treatment duration was 19 months (95 % CI: 16-22), with a treatment survival of 56 % at 28 months, and remission and response rates at 24 months of 53.8 % and 61.5 %. Twenty-three treatments were withdrawn, most of them (18) during the induction period. There were adverse events in a quarter of the patients; only four were severe and led to treatment discontinuation. tofacitinib has a demonstrated efficacy in clinical practice to induce and maintain clinical response in treatment-refractory UC patients, with an acceptable safety profile.
%K Área de Gestión Sanitaria Norte de Almería
%K Tofacitinib
%K Ulcerative colitis
%K Real-life
%~