RT Journal Article
T1 Role of S100B protein in urine and serum as an early predictor of mortality after severe traumatic brain injury in adults
A1 Rodriguez-Rodriguez, Ana
A1 Egea-Guerrero, Juan Jose
A1 Leon-Justel, Antonio
A1 Gordillo-Escobar, Elena
A1 Revuelto-Rey, Jaume
A1 Vilches-Arenas, Angel
A1 Carrillo-Vico, Antonio
A1 Dominguez-Roldan, Jose Maria
A1 Murillo-Cabezas, Francisco
A1 Guerrero, Juan Miguel
K1 Traumatic brain injury
K1 S100B
K1 Urine
K1 Mortality
K1 Biomarcadores
K1 Biomarkers
K1 Lesiones traumáticas del encéfalo
K1 Orina
K1 Mortalidad
AB S100B is a calcium-binding protein released into the blood from astroglial cells due to brain injury. Some authors have described a correlation between S100B serum concentration and severity of brain damage. There is not much information about the accuracy of urinary S100B for predicting outcome after severe traumatic brain injury (TBI). 55 patients with severe TBI were included in the study. Blood and urine samples were drawn to determine S100B levels on admission and on the subsequent 24, 48, 72 and 96 h. S100B concentrations (serum and urine) were significantly higher in patients who were dead a month after the accident compared to survivors. ROC-analysis showed that S100B at 24 h post-severe TBI is a useful tool for predicting mortality (serum: AUC 0.958, urine: AUC 0.778). The best cut-offs for S100B were 0.461 μg/L and 0.025 μg/L (serum and urine respectively), with a sensitivity of 90% for both measurements and a specificity of 88.4% (serum) and 62.8% (urine). We can state that the determination of S100B levels both in urine and serum acts as a sensitive and an effective biomarker for the early prediction of mortality after severe TBI.
PB Elsevier
SN 0009-8981
YR 2012
FD 2012-09-29
LK https://hdl.handle.net/10668/23223
UL https://hdl.handle.net/10668/23223
LA en
NO Rodríguez-Rodríguez A, Egea-Guerrero JJ, León-Justel A, Gordillo-Escobar E, Revuelto-Rey J, Vilches-Arenas A, et al. Role of S100B protein in urine and serum as an early predictor of mortality after severe traumatic brain injury in adults. Clin Chim Acta. 2012 Dec 24;414:228-33
DS RISalud
RD Apr 5, 2025