RT Journal Article
T1 Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications.
A1 Medrano, Mayte
A1 Carrillo-Cruz, Estrella
A1 Montero, Isabel
A1 Perez-Simon, Jose A
K1 allogeneic stem cell transplantation
K1 haematopoiesis
K1 leukaemia
K1 myelodysplastic syndrome
K1 vitamin D
AB Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). It plays a main role in the calcium homeostasis and metabolism. In addition, vitamin D display other important effects called "non-classical actions." Among them, vitamin D regulates immune cells function and hematopoietic cells differentiation and proliferation. Based on these effects, it is currently being evaluated for the treatment of hematologic malignancies. In addition, vitamin D levels have been correlated with patients' outcome after allogeneic stem cell transplantation, where it might regulate immune response and, accordingly, might influence the risk of graft-versus-host disease. Here, we present recent advances regarding its clinical applications both in the treatment of hematologic malignancies and in the transplant setting.
YR 2018
FD 2018-09-08
LK http://hdl.handle.net/10668/12931
UL http://hdl.handle.net/10668/12931
LA en
DS RISalud
RD Apr 8, 2025