RT Journal Article
T1 Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.
A1 Mullins, Niamh
A1 Kang, JooEun
A1 Campos, Adrian I
A1 Coleman, Jonathan R I
A1 Edwards, Alexis C
A1 Galfalvy, Hanga
A1 Levey, Daniel F
A1 Lori, Adriana
A1 Shabalin, Andrey
A1 Starnawska, Anna
A1 Su, Mei-Hsin
A1 Watson, Hunna J
A1 Adams, Mark
A1 Awasthi, Swapnil
A1 Gandal, Michael
A1 Hafferty, Jonathan D
A1 Hishimoto, Akitoyo
A1 Kim, Minsoo
A1 Okazaki, Satoshi
A1 Otsuka, Ikuo
A1 Ripke, Stephan
A1 Ware, Erin B
A1 Bergen, Andrew W
A1 Berrettini, Wade H
A1 Bohus, Martin
A1 Brandt, Harry
A1 Chang, Xiao
A1 Chen, Wei J
A1 Chen, Hsi-Chung
A1 Crawford, Steven
A1 Crow, Scott
A1 DiBlasi, Emily
A1 Duriez, Philibert
A1 Fernandez-Aranda, Fernando
A1 Fichter, Manfred M
A1 Gallinger, Steven
A1 Glatt, Stephen J
A1 Gorwood, Philip
A1 Guo, Yiran
A1 Hakonarson, Hakon
A1 Halmi, Katherine A
A1 Hwu, Hai-Gwo
A1 Jain, Sonia
A1 Jamain, Stéphane
A1 Jimenez-Murcia, Susana
A1 Johnson, Craig
A1 Kaplan, Allan S
A1 Kaye, Walter H
A1 Keel, Pamela K
A1 Kennedy, James L
A1 Klump, Kelly L
A1 Li, Dong
A1 Liao, Shih-Cheng
A1 Lieb, Klaus
A1 Lilenfeld, Lisa
A1 Liu, Chih-Min
A1 Magistretti, Pierre J
A1 Marshall, Christian R
A1 Mitchell, James E
A1 Monson, Eric T
A1 Myers, Richard M
A1 Pinto, Dalila
A1 Powers, Abigail
A1 Ramoz, Nicolas
A1 Roepke, Stefan
A1 Rozanov, Vsevolod
A1 Scherer, Stephen W
A1 Schmahl, Christian
A1 Sokolowski, Marcus
A1 Strober, Michael
A1 Thornton, Laura M
A1 Treasure, Janet
A1 Tsuang, Ming T
A1 Witt, Stephanie H
A1 Woodside, D Blake
A1 Yilmaz, Zeynep
A1 Zillich, Lea
A1 Adolfsson, Rolf
A1 Agartz, Ingrid
A1 Air, Tracy M
A1 Alda, Martin
A1 Alfredsson, Lars
A1 Andreassen, Ole A
A1 Anjorin, Adebayo
A1 Appadurai, Vivek
A1 Soler Artigas, María
A1 Van der Auwera, Sandra
A1 Azevedo, M Helena
A1 Bass, Nicholas
A1 Bau, Claiton H D
A1 Baune, Bernhard T
A1 Bellivier, Frank
A1 Berger, Klaus
A1 Biernacka, Joanna M
A1 Bigdeli, Tim B
A1 Binder, Elisabeth B
A1 Boehnke, Michael
A1 Boks, Marco P
A1 Bosch, Rosa
A1 Braff, David L
A1 Bryant, Richard
A1 Budde, Monika
A1 Byrne, Enda M
A1 Cahn, Wiepke
A1 Casas, Miguel
A1 Castelao, Enrique
A1 Cervilla, Jorge A
A1 Chaumette, Boris
A1 Cichon, Sven
A1 Corvin, Aiden
A1 Craddock, Nicholas
A1 Craig, David
A1 Degenhardt, Franziska
A1 Djurovic, Srdjan
A1 Edenberg, Howard J
A1 Fanous, Ayman H
A1 Foo, Jerome C
A1 Forstner, Andreas J
A1 Frye, Mark
A1 Fullerton, Janice M
A1 Gatt, Justine M
A1 Gejman, Pablo V
A1 Giegling, Ina
A1 Grabe, Hans J
A1 Green, Melissa J
A1 Grevet, Eugenio H
A1 Grigoroiu-Serbanescu, Maria
A1 Gutierrez, Blanca
A1 Guzman-Parra, Jose
A1 Hamilton, Steven P
A1 Hamshere, Marian L
A1 Hartmann, Annette
A1 Hauser, Joanna
A1 Heilmann-Heimbach, Stefanie
A1 Hoffmann, Per
A1 Ising, Marcus
A1 Jones, Ian
A1 Jones, Lisa A
A1 Jonsson, Lina
A1 Kahn, Rene S
A1 Kelsoe, John R
A1 Kendler, Kenneth S
A1 Kloiber, Stefan
A1 Koenen, Karestan C
A1 Kogevinas, Manolis
A1 Konte, Bettina
A1 Krebs, Marie-Odile
A1 Landen, Mikael
A1 Lawrence, Jacob
A1 Leboyer, Marion
A1 Lee, Phil H
A1 Levinson, Douglas F
A1 Liao, Calwing
A1 Lissowska, Jolanta
A1 Lucae, Susanne
A1 Mayoral, Fermin
A1 McElroy, Susan L
A1 McGrath, Patrick
A1 McGuffin, Peter
A1 McQuillin, Andrew
A1 Medland, Sarah E
A1 Mehta, Divya
A1 Melle, Ingrid
A1 Milaneschi, Yuri
A1 Mitchell, Philip B
A1 Molina, Esther
A1 Morken, Gunnar
A1 Mortensen, Preben Bo
A1 Müller-Myhsok, Bertram
A1 Nievergelt, Caroline
A1 Nimgaonkar, Vishwajit
A1 Nöthen, Markus M
A1 O'Donovan, Michael C
A1 Ophoff, Roel A
A1 Owen, Michael J
A1 Pato, Carlos
A1 Pato, Michele T
A1 Penninx, Brenda W J H
A1 Pimm, Jonathan
A1 Pistis, Giorgio
A1 Potash, James B
A1 Power, Robert A
A1 Preisig, Martin
A1 Quested, Digby
A1 Ramos-Quiroga, Josep Antoni
A1 Reif, Andreas
A1 Ribases, Marta
A1 Richarte, Vanesa
A1 Rietschel, Marcella
A1 Rivera, Margarita
A1 Roberts, Andrea
A1 Roberts, Gloria
A1 Rouleau, Guy A
A1 Rovaris, Diego L
A1 Rujescu, Dan
A1 Sanchez-Mora, Cristina
A1 Sanders, Alan R
A1 Schofield, Peter R
A1 Schulze, Thomas G
A1 Scott, Laura J
A1 Serretti, Alessandro
A1 Shi, Jianxin
A1 Shyn, Stanley I
A1 Sirignano, Lea
A1 Sklar, Pamela
A1 Smeland, Olav B
A1 Smoller, Jordan W
A1 Sonuga-Barke, Edmund J S
A1 Spalletta, Gianfranco
A1 Strauss, John S
A1 Świątkowska, Beata
A1 Trzaskowski, Maciej
A1 Turecki, Gustavo
A1 Vilar-Ribo, Laura
A1 Vincent, John B
A1 Völzke, Henry
A1 Walters, James T R
A1 Shannon-Weickert, Cynthia
A1 Weickert, Thomas W
A1 Weissman, Myrna M
A1 Williams, Leanne M
A1 Wray, Naomi R
A1 Zai, Clement C
A1 Ashley-Koch, Allison E
A1 Beckham, Jean C
A1 Hauser, Elizabeth R
A1 Hauser, Michael A
A1 Kimbrel, Nathan A
A1 Lindquist, Jennifer H
A1 McMahon, Benjamin
A1 Oslin, David W
A1 Qin, Xuejun
A1 Agerbo, Esben
A1 Børglum, Anders D
A1 Breen, Gerome
A1 Erlangsen, Annette
A1 Esko, Tonu
A1 Gelernter, Joel
A1 Hougaard, David M
A1 Kessler, Ronald C
A1 Kranzler, Henry R
A1 Li, Qingqin S
A1 Martin, Nicholas G
A1 McIntosh, Andrew M
A1 Mors, Ole
A1 Nordentoft, Merete
A1 Olsen, Catherine M
A1 Porteous, David
A1 Ursano, Robert J
A1 Wasserman, Danuta
A1 Werge, Thomas
A1 Whiteman, David C
A1 Bulik, Cynthia M
A1 Coon, Hilary
A1 Demontis, Ditte
A1 Docherty, Anna R
A1 Kuo, Po-Hsiu
A1 Lewis, Cathryn M
A1 Mann, J John
A1 Rentería, Miguel E
A1 Smith, Daniel J
A1 Stahl, Eli A
A1 Stein, Murray B
A1 Streit, Fabian
A1 Willour, Virginia
A1 Ruderfer, Douglas M
K1 Genetic correlation
K1 Genome-wide association study
K1 Pleiotropy
K1 Polygenicity
K1 Suicide
K1 Suicide attempt
AB Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.
PB Elsevier
YR 2022
FD 2022-02-17
LK http://hdl.handle.net/10668/22055
UL http://hdl.handle.net/10668/22055
LA en
NO Mullins N, Kang J, Campos AI, Coleman JRI, Edwards AC, Galfalvy H, et al. Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors. Biol Psychiatry. 2022 Feb 1;91(3):313-327
NO Which is supported by the Office of Research Infrastructure of the National Institutes of Health (Grant Nos. S10OD018522 and S10OD026880). This work was conducted in part using the resources of the Advanced Computing Center for Research and Education at Vanderbilt University, Nashville, TN. This work was funded by the National Institutes of Health (Grant Nos. R01MH116269 and R01MH121455 [to DMR]), NIGMS of the National Institutes of Health (Grant No. T32GM007347 [to JK]), and the Brain & Behavior Research Foundation (NARSAD Young Investigator Award No. 29551 [to NM]).
DS RISalud
RD May 13, 2025