RT Journal Article
T1 Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals.
A1 McWhinney, Sean R
A1 Brosch, Katharina
A1 Calhoun, Vince D
A1 Crespo-Facorro, Benedicto
A1 Crossley, Nicolas A
A1 Dannlowski, Udo
A1 Dickie, Erin
A1 Dietze, Lorielle M F
A1 Donohoe, Gary
A1 Du Plessis, Stefan
A1 Ehrlich, Stefan
A1 Emsley, Robin
A1 Furstova, Petra
A1 Glahn, David C
A1 Gonzalez-Valderrama, Alfonso
A1 Grotegerd, Dominik
A1 Holleran, Laurena
A1 Kircher, Tilo T J
A1 Knytl, Pavel
A1 Kolenic, Marian
A1 Lencer, Rebekka
A1 Nenadić, Igor
A1 Opel, Nils
A1 Pfarr, Julia-Katharina
A1 Rodrigue, Amanda L
A1 Rootes-Murdy, Kelly
A1 Ross, Alex J
A1 Sim, Kang
A1 Škoch, Antonín
A1 Spaniel, Filip
A1 Stein, Frederike
A1 Švancer, Patrik
A1 Tordesillas-Gutiérrez, Diana
A1 Undurraga, Juan
A1 Vázquez-Bourgon, Javier
A1 Voineskos, Aristotle
A1 Walton, Esther
A1 Weickert, Thomas W
A1 Weickert, Cynthia Shannon
A1 Thompson, Paul M
A1 van Erp, Theo G M
A1 Turner, Jessica A
A1 Hajek, Tomas
AB Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained MRI-derived brain cortical and subcortical measures and body mass index (BMI) from 1260 individuals with schizophrenia and 1761 controls from 12 independent research sites within the ENIGMA-Schizophrenia Working Group. We jointly modeled the statistical effects of schizophrenia and BMI using mixed effects. BMI was additively associated with structure of many of the same brain regions as schizophrenia, but the cortical and subcortical alterations in schizophrenia were more widespread and pronounced. Both BMI and schizophrenia were primarily associated with changes in cortical thickness, with fewer correlates in surface area. While, BMI was negatively associated with cortical thickness, the significant associations between BMI and surface area or subcortical volumes were positive. Lastly, the brain correlates of obesity were replicated among large studies and closely resembled neurostructural changes in major depressive disorders. We confirmed widespread associations between BMI and brain structure in individuals with schizophrenia. People with both obesity and schizophrenia showed more pronounced brain alterations than people with only one of these conditions. Obesity appears to be a relevant factor which could account for heterogeneity of brain imaging findings and for differences in brain imaging outcomes among people with schizophrenia.
YR 2022
FD 2022-06-14
LK http://hdl.handle.net/10668/22601
UL http://hdl.handle.net/10668/22601
LA en
DS RISalud
RD Apr 19, 2025