RT Journal Article
T1 ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents.
A1 Barja-Fernández, Silvia
A1 Folgueira, Cintia
A1 Castelao, Cecilia
A1 Pena-León, Verónica
A1 González-Saenz, Patricia
A1 Vázquez-Cobela, Rocío
A1 Aguilera, Concepción M
A1 Gil-Campos, Mercedes
A1 Bueno, Gloria
A1 Gil, Ángel
A1 Moreno, Luis A
A1 Ruiz-Piñon, Manuel
A1 García-Palacios, María
A1 Casanueva, Felipe F
A1 Diéguez, Carlos
A1 Nogueiras, Rubén
A1 Leis, Rosaura
A1 Seoane, Luisa M
K1 ANGPTL-4
K1 BMI loss
K1 childhood
K1 lipid profile
K1 obesity
AB Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two different cohorts. In the first cohort (n = 150, age 3-17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5-18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile.
YR 2019
FD 2019-06-14
LK http://hdl.handle.net/10668/14128
UL http://hdl.handle.net/10668/14128
LA en
DS RISalud
RD Apr 19, 2025