RT Journal Article
T1 Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort.
A1 Zamora-Ros, Raul
A1 Barupal, Dinesh K
A1 Rothwell, Joseph A
A1 Jenab, Mazda
A1 Fedirko, Veronika
A1 Romieu, Isabelle
A1 Aleksandrova, Krasimira
A1 Overvad, Kim
A1 Kyrø, Cecilie
A1 Tjønneland, Anne
A1 Affret, Aurélie
A1 His, Mathilde
A1 Boutron-Ruault, Marie-Christine
A1 Katzke, Verena
A1 Kühn, Tilman
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Naska, Androniki
A1 Kritikou, Maria
A1 Saieva, Calogero
A1 Agnoli, Claudia
A1 Santucci de Magistris, Maria
A1 Tumino, Rosario
A1 Fasanelli, Francesca
A1 Weiderpass, Elisabete
A1 Skeie, Guri
A1 Merino, Susana
A1 Jakszyn, Paula
A1 Sanchez-Perez, Maria-Jose
A1 Dorronsoro, Miren
A1 Navarro, Carmen
A1 Ardanaz, Eva
A1 Sonestedt, Emily
A1 Ericson, Ulrika
A1 Maria Nilsson, Lena
A1 Bodén, Stina
A1 Bueno-de-Mesquita, H B As
A1 Peeters, Petra H
A1 Perez-Cornago, Aurora
A1 Wareham, Nicholas J
A1 Khaw, Kay-Thee
A1 Freisling, Heinz
A1 Cross, Amanda J
A1 Riboli, Elio
A1 Scalbert, Augustin
K1 EPIC
K1 colorectal cancer
K1 diet
K1 flavonoids
K1 prospective cohort
AB Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.
YR 2017
FD 2017-01-19
LK http://hdl.handle.net/10668/10710
UL http://hdl.handle.net/10668/10710
LA en
DS RISalud
RD Apr 6, 2025