RT Journal Article
T1 Plasma lipidome patterns associated with cardiovascular risk in the PREDIMED trial: A case-cohort study.
A1 Razquin, Cristina
A1 Liang, Liming
A1 Toledo, Estefanía
A1 Clish, Clary B
A1 Ruiz-Canela, Miguel
A1 Zheng, Yan
A1 Wang, Dong D
A1 Corella, Dolores
A1 Castaner, Olga
A1 Ros, Emilio
A1 Aros, Fernando
A1 Gomez-Gracia, Enrique
A1 Fiol, Miquel
A1 Santos-Lozano, José Manuel
A1 Guasch-Ferre, Marta
A1 Serra-Majem, Lluis
A1 Sala-Vila, Aleix
A1 Buil-Cosiales, Pilar
A1 Bullo, Monica
A1 Fito, Montserrat
A1 Portoles, Olga
A1 Estruch, Ramon
A1 Salas-Salvado, Jordi
A1 Hu, Frank B
A1 Martinez-Gonzalez, Miguel A
K1 Cardiovascular disease
K1 Case-cohort
K1 Lipidomics
K1 Mediterranean diet
K1 Primary prevention
AB The study of the plasma lipidome may help to better characterize molecular mechanisms underlying cardiovascular disease. The identification of new lipid biomarkers could provide future targets for prevention and innovative therapeutic approaches. In the frame of the PREDIMED trial, our aim was to examine the associations of baseline lipidome patterns or their changes with the risk of clinical CVD events. We included 983 participants in our case-cohort study. The end-point was the incidence of major CVD during 4.8years of median follow-up. We repeatedly measured 202 plasma known lipid metabolites at baseline and after 1-year of intervention. Principal component analysis was used to identify lipidome factors. Among the 15 identified factors, 7 were significantly associated with CVD. Considering common patterns among factors, lipids were grouped (summed) into scores. After adjustment for traditional CVD risk factors, scores of baseline polyunsaturated phosphatidylcholines (PC)/lysoPC/PC-plasmalogens and polyunsaturated cholesterol esters (CE) showed inverse associations with CVD (p=0.036 and 0.012, respectively); whereas scores of monoacylglycerols (MAGs)/diacylglycerols (DAGs) and short triacylglycerols (TAGs) showed a direct association with CVD (p=0.026 and 0.037, respectively). Baseline phosphatidylethanolamines (PEs) and their 1-y changes tended to be associated with higher CVD risk (p=0.066 and 0.081, respectively). We did not find a significant effect of the intervention with the Mediterranean Diet on these scores. Our study suggests that polyunsaturated PCs and CEs may confer protection against CVD. In contrast, MAGs, DAGs, TAGs and PEs appeared to be associated with higher CVD risk.
YR 2018
FD 2018
LK http://hdl.handle.net/10668/11975
UL http://hdl.handle.net/10668/11975
LA en
DS RISalud
RD Apr 9, 2025