RT Journal Article
T1 Gut Microbiota Composition Is Associated With the Global DNA Methylation Pattern in Obesity.
A1 Ramos-Molina, Bruno
A1 Sánchez-Alcoholado, Lidia
A1 Cabrera-Mulero, Amanda
A1 Lopez-Dominguez, Raul
A1 Carmona-Saez, Pedro
A1 Garcia-Fuentes, Eduardo
A1 Moreno-Indias, Isabel
A1 Tinahones, Francisco J
K1 adipose tissue
K1 epigenetics
K1 gut microbiota
K1 methylation
K1 obesity
AB Objective: Obesity and obesity-related metabolic diseases are characterized by gut microbiota and epigenetic alterations. Recent insight has suggested the existence of a crosstalk between the gut microbiome and the epigenome. However, the possible link between alterations in gut microbiome composition and epigenetic marks in obesity has been not explored yet. The aim of this work is to establish a link between the gut microbiota and the global DNA methylation profile in a group of obese subjects and to report potential candidate genes that could be epigenetically regulated by gut microbiota in adipose tissue. Methods: Gut microbiota composition was analyzed in DNA stool samples from 45 obese subjects by 16S ribosomal RNA (rRNA) gene sequencing. Twenty patients were selected based on their Bacteroidetes-to-Firmicutes ratio (BFR): HighBFR group (BFR > 2.5, n = 10) and LowBFR group (BFR  2.5, n = 10) and LowBFR group (BFR
SN 1664-8021
YR 2019
FD 2019-07-03
LK http://hdl.handle.net/10668/14288
UL http://hdl.handle.net/10668/14288
LA en
DS RISalud
RD Apr 18, 2025