RT Journal Article
T1 Oxidative stress in the pathogenesis of atherothrombosis associated with anti-phospholipid syndrome and systemic lupus erythematosus: new therapeutic approaches.
A1 Lopez-Pedrera, Chary
A1 Barbarroja, Nuria
A1 Jimenez-Gomez, Yolanda
A1 Collantes-Estevez, Eduardo
A1 Aguirre, Ma Angeles
A1 Cuadrado, Ma Jose
K1 anti-phospholipid syndrome
K1 atherothrombosis
K1 oxidative stress
K1 systemic lupus erythematosus
K1 therapeutic approaches
AB Atherothrombosis is a recurrent complication in APS and SLE patients. Oxidative stress has been suggested as a key player underlying this process. Autoantibodies have been pointed to as the main contributors to abnormality in the oxidative status observed in APS and SLE patients, promoting the increased production of oxidant species and the reduction of antioxidant molecules. This imbalance causes vascular damage through the activation of immune cells, including monocytes, lymphocytes and neutrophils, causing the expression of pro-inflammatory and procoagulant molecules, the formation of neutrophil extracellular traps and the adhesion of these cells to the endothelium; the induction of cellular apoptosis and impaired cell clearance, which in turn enhances autoantibody neogeneration; and cytotoxicity of endothelial cells. This review describes the mechanisms underlying the role of oxidative stress in the pathogenesis of atherothrombosis associated with APS and SLE, focused on the effect of autoantibodies, the different cell types involved and the diverse effectors, including cytokines, procoagulant proteins and their main modulators, such as oxidant/antioxidant species and intracellular pathways in each pathology. We further discuss new therapies aimed at restoring the oxidative stress balance and subsequently to tackle atherothrombosis in APS and SLE.
PB Oxford University Press
YR 2016
FD 2016-03-27
LK http://hdl.handle.net/10668/9947
UL http://hdl.handle.net/10668/9947
LA en
NO López-Pedrera C, Barbarroja N, Jimenez-Gomez Y, Collantes-Estevez E, Aguirre MA, Cuadrado MJ. Oxidative stress in the pathogenesis of atherothrombosis associated with anti-phospholipid syndrome and systemic lupus erythematosus: new therapeutic approaches. Rheumatology (Oxford). 2016 Dec;55(12):2096-2108.
DS RISalud
RD Apr 7, 2025