TY  - JOUR
AU  - Torres-Odio, Sylvia
AU  - Key, Jana
AU  - Hoepken, Hans-Hermann
AU  - Canet-Pons, Júlia
AU  - Valek, Lucie
AU  - Roller, Bastian
AU  - Walter, Michael
AU  - Morales-Gordo, Blas
AU  - Meierhofer, David
AU  - Harter, Patrick N
AU  - Mittelbronn, Michel
AU  - Tegeder, Irmgard
AU  - Gispert, Suzana
AU  - Auburger, Georg
PY  - 2017
DO  - 10.1186/s12974-017-0928-0
UR  - http://hdl.handle.net/10668/11465
T2  - Journal of neuroinflammation
AB  - PINK1 deficiency causes the autosomal recessive PARK6 variant of Parkinson's disease. PINK1 activates ubiquitin by phosphorylation and cooperates with the downstream ubiquitin ligase PARKIN, to exert quality control and control autophagic degradation...
LA  - en
KW  - Antiviral response
KW  - Mitochondrial dysfunction
KW  - Neuroinflammation
KW  - Parkinson’s disease
KW  - Ubiquitin kinase PINK1
KW  - Age Factors
KW  - Aging
KW  - Animals
KW  - Calcium-Binding Proteins
KW  - Cells, Cultured
KW  - Cerebral Cortex
KW  - Disease Models, Animal
KW  - Disease Progression
KW  - Endoplasmic Reticulum Stress
KW  - Gene Expression Profiling
KW  - Humans
KW  - Lipid Metabolism
KW  - Mice
KW  - Mice, Transgenic
KW  - Microfilament Proteins
KW  - Mitophagy
KW  - Neuroblastoma
KW  - Neurons
KW  - Parkinson Disease
KW  - Protein Kinases
KW  - RNA Splicing
KW  - Ubiquitination
KW  - alpha-Synuclein
TI  - Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.
TY  - research article
VL  - 14
ER  -