RT Journal Article
T1 Interaction between cardiovascular risk factors and body mass index and 10-year incidence of cardiovascular disease, cancer death, and overall mortality.
A1 Barroso, Maria
A1 Goday, Albert
A1 Ramos, Rafel
A1 Marín-Ibañez, Alejandro
A1 Guembe, Maria Jesús
A1 Rigo, Fernando
A1 Tormo-Díaz, Maria José
A1 Moreno-Iribas, Conchi
A1 Cabré, Joan Josep
A1 Segura, Antonio
A1 Baena-Díez, Jose Miguel
A1 de la Cámara, Agustín Gómez
A1 Lapetra, José
A1 Quesada, Miquel
A1 Medrano, María José
A1 Berjón, Jesús
A1 Frontera, Guillem
A1 Gavrila, Diana
A1 Barricarte, Aurelio
A1 Basora, Josep
A1 García, José María
A1 García-Lareo, Manel
A1 Lora-Pablos, David
A1 Mayoral, Eduardo
A1 Grau, María
A1 Marrugat, Jaume
A1 FRESCO Investigators, 
K1 Body mass index
K1 Cardiovascular disease
K1 Epidemiology
K1 Mortality
K1 Neoplasms
K1 Obesity
AB The effect of above-normal body mass index (BMI) on health outcomes is controversial because it is difficult to distinguish from the effect due to BMI-associated cardiovascular risk factors. The objective was to analyze the impact on 10-year incidence of cardiovascular disease, cancer deaths and overall mortality of the interaction between cardiovascular risk factors and BMI. We conducted a pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35-79years old at basal examination. Body mass index was measured at baseline being the outcome measures ten-year cardiovascular disease, cancer and overall mortality. Multivariable analyses were adjusted for potential confounders, considering the significant interactions with cardiovascular risk factors. We included 54,446 individuals (46.5% with overweight and 27.8% with obesity). After considering the significant interactions, the 10-year risk of cardiovascular disease was significantly increased in women with overweight and obesity [Hazard Ratio=2.34 (95% confidence interval: 1.19-4.61) and 5.65 (1.54-20.73), respectively]. Overweight and obesity significantly increased the risk of cancer death in women [3.98 (1.53-10.37) and 11.61 (1.93-69.72)]. Finally, obese men had an increased risk of cancer death and overall mortality [1.62 (1.03-2.54) and 1.34 (1.01-1.76), respectively]. In conclusion, overweight and obesity significantly increased the risk of cancer death and of fatal and non-fatal cardiovascular disease in women; whereas obese men had a significantly higher risk of death for all causes and for cancer. Cardiovascular risk factors may act as effect modifiers in these associations.
YR 2017
FD 2017-11-16
LK http://hdl.handle.net/10668/11816
UL http://hdl.handle.net/10668/11816
LA en
DS RISalud
RD Apr 5, 2025