%0 Journal Article
%A Barroso, Maria
%A Goday, Albert
%A Ramos, Rafel
%A Marín-Ibañez, Alejandro
%A Guembe, Maria Jesús
%A Rigo, Fernando
%A Tormo-Díaz, Maria José
%A Moreno-Iribas, Conchi
%A Cabré, Joan Josep
%A Segura, Antonio
%A Baena-Díez, Jose Miguel
%A de la Cámara, Agustín Gómez
%A Lapetra, José
%A Quesada, Miquel
%A Medrano, María José
%A Berjón, Jesús
%A Frontera, Guillem
%A Gavrila, Diana
%A Barricarte, Aurelio
%A Basora, Josep
%A García, José María
%A García-Lareo, Manel
%A Lora-Pablos, David
%A Mayoral, Eduardo
%A Grau, María
%A Marrugat, Jaume
%A FRESCO Investigators
%T Interaction between cardiovascular risk factors and body mass index and 10-year incidence of cardiovascular disease, cancer death, and overall mortality.
%D 2017
%U http://hdl.handle.net/10668/11816
%X The effect of above-normal body mass index (BMI) on health outcomes is controversial because it is difficult to distinguish from the effect due to BMI-associated cardiovascular risk factors. The objective was to analyze the impact on 10-year incidence of cardiovascular disease, cancer deaths and overall mortality of the interaction between cardiovascular risk factors and BMI. We conducted a pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35-79years old at basal examination. Body mass index was measured at baseline being the outcome measures ten-year cardiovascular disease, cancer and overall mortality. Multivariable analyses were adjusted for potential confounders, considering the significant interactions with cardiovascular risk factors. We included 54,446 individuals (46.5% with overweight and 27.8% with obesity). After considering the significant interactions, the 10-year risk of cardiovascular disease was significantly increased in women with overweight and obesity [Hazard Ratio=2.34 (95% confidence interval: 1.19-4.61) and 5.65 (1.54-20.73), respectively]. Overweight and obesity significantly increased the risk of cancer death in women [3.98 (1.53-10.37) and 11.61 (1.93-69.72)]. Finally, obese men had an increased risk of cancer death and overall mortality [1.62 (1.03-2.54) and 1.34 (1.01-1.76), respectively]. In conclusion, overweight and obesity significantly increased the risk of cancer death and of fatal and non-fatal cardiovascular disease in women; whereas obese men had a significantly higher risk of death for all causes and for cancer. Cardiovascular risk factors may act as effect modifiers in these associations.
%K Body mass index
%K Cardiovascular disease
%K Epidemiology
%K Mortality
%K Neoplasms
%K Obesity
%~