TY - JOUR AU - Gonzalez-Aparicio, Ramiro AU - Blanco, Eduardo AU - Serrano, Antonia AU - Pavon, Francisco Javier AU - Parsons, Loren H AU - Maldonado, Rafael AU - Robledo, Patricia AU - Fernandez-Espejo, Emilio AU - Rodríguez de Fonseca, Fernando PY - 2014 DO - 10.1017/S1461145713001259 SN - 1461-1457 UR - http://hdl.handle.net/10668/1980 T2 - The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) AB - Oleoylethanolamide (OEA) is an agonist of the peroxisome proliferator-activated receptor α (PPARα) and has been described to exhibit neuroprotective properties when administered locally in animal models of several neurological disorder models,... LA - en PB - Oxford University Press KW - Dopaminergic neurons KW - Neuroprotection KW - Parkinson's disease KW - PPARx KW - Modelos de enfermedad en animales KW - Relación dosis-respuesta de medicamentos KW - Actividad motora KW - Neurotoxinas KW - Ácidos oleicos KW - Trastornos parkinsonianos KW - Sustancia negra KW - Sinaptofisina KW - Medical Subject Headings::Anatomy::Cells::Cells, Cultured KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Basal Ganglia::Corpus Striatum KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Animal::Disease Models, Animal KW - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Dose-Response Relationship, Drug KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxygenases::Mixed Function Oxygenases::Heme Oxygenase (Decyclizing)::Heme Oxygenase-1 KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Alcohol Oxidoreductases::Lactate Dehydrogenases::L-Lactate Dehydrogenase KW - Medical Subject Headings::Check Tags::Male KW - Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity KW - Medical Subject Headings::Anatomy::Nervous System::Neurons KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Neuroprotective Agents KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Noxae::Neurotoxins KW - Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Fatty Acids, Monounsaturated::Oleic Acids KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::Catecholamines::Dopamine::Hydroxydopamines::Oxidopamine KW - Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Mesencephalon::Tegmentum Mesencephali::Substantia Nigra KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Synaptophysin KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxygenases::Mixed Function Oxygenases::Tyrosine 3-Monooxygenase KW - Medical Subject Headings::Organisms::Eukaryota TI - The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism. TY - research article ER -