%0 Journal Article
%A Poddubnyy, Denis
%A Pournara, Effie
%A Zielińska, Agnieszka
%A Baranauskaite, Asta
%A Jiménez, Alejandro Muñoz
%A Sadhu, Sanchayita
%A Schulz, Barbara
%A Rissler, Michael
%A Perella, Chiara
%A Marzo-Ortega, Helena
%T Rapid improvement in spinal pain in patients with axial spondyloarthritis treated with secukinumab: primary results from a randomized controlled phase-IIIb trial.
%D 2021
%@ 1759-720X
%U https://hdl.handle.net/10668/27317
%X This study aimed to evaluate the efficacy and safety of secukinumab 150 mg compared with placebo in the management of spinal pain and disease activity in patients with axial spondyloarthritis (axSpA) at Week 8 and up to Week 24. Patients (n = 380) with active axSpA were randomized (3:1) to secukinumab 150 mg (Group A) or placebo (Group B). At Week 8, patients from Group A with an average spinal pain score  At Week 8, the odds of achieving an average spinal pain score of  Secukinumab provided rapid and significant improvement in spinal pain at Week 8 which was sustained or increased further up to Week 24 in patients with axSpA. ClinicalTrials.gov: NCT03136861. Registered May 2, 2017.
%K axial spondyloarthritis
%K interleukin-17A inhibitor
%K spinal pain
%K tumour necrosis factor inhibitor
%~