RT Journal Article
T1 In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC.
A1 Briales, A
A1 Rodríguez-Martínez, J M
A1 Velasco, C
A1 Díaz de Alba, P
A1 Domínguez-Herrera, J
A1 Pachón, J
A1 Pascual, A
K1 Pruebas de sensibilidad microbiana
K1 Mutación
K1 Ciprofloxacino
AB This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant Ser83Leu substitutions in GyrA and/or Ser80Arg in ParC, on fluoroquinolone (FQ) resistance in isogenic Escherichia coli strains. The association of Ser83Leu substitution in GyrA, Ser80Arg substitution in ParC, and qnr gene expression increased the MIC of ciprofloxacin to 2 μg/ml. qnr genes present in E. coli that harbored a Ser83Leu substitution in GyrA increased mutant prevention concentration (MPC) values to 8 to 32 μg/ml. qnr gene expression in E. coli may play an important role in selecting for one-step FQ-resistant mutants.
PB American Society for Microbiology
SN 0066-4804
YR 2011
FD 2011-03
LK http://hdl.handle.net/10668/2364
UL http://hdl.handle.net/10668/2364
LA en
NO Briales A, Rodríguez-Martínez JM, Velasco C, Díaz de Alba P, Domínguez-Herrera J, Pachón J, et al. In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. Antimicrob. Agents Chemother. 2011; 55(3):1266-9
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 17, 2025