%0 Journal Article
%A Petrova, Dafina
%A Ubago-Guisado, Esther
%A Garcia-Retamero, Rocio
%A Redondo-Sánchez, Daniel
%A Pérez-Gómez, Beatriz
%A Catena, Andrés
%A Caparros-Gonzalez, Rafael A
%A Sanchez-Perez, Maria-Jose
%T Allostatic Load and Depression Symptoms in Cancer Survivors: A National Health and Nutrition Examination Survey Study.
%D 2023
%U https://hdl.handle.net/10668/24316
%X Background: Individuals with cancer often experience stress throughout the cancer trajectory and have a high risk of experiencing depression.Objective: The aim of this study was to examine the relationship between allostatic load (AL), a measure of cumulative stress-related physiologic dysregulation of different body systems, and symptoms of depression in cancer survivors.Methods: Participants were 294 adult cancer survivors from the US National Health and Nutrition Examination Survey (NHANES 2007-2018). Allostatic load was measured using 14 indicators representing cardiometabolic risk, glucose metabolism, cardiopulmonary functioning, parasympathetic functioning, and inflammation. Depressive symptoms were measured with the Patient Health Questionnaire-9. The relationship between AL and depressive symptoms was investigated using multiple regression adjusted for diverse sociodemographic and diagnosis variables.Results: Higher AL was associated with higher depressive symptom scores. The higher risk of depression was concentrated among those survivors in the highest AL quartile, with 21% (95% confidence interval, 11%-32%) of survivors presenting a high risk of depression compared with 8% to 11% of survivors in the lower quartiles. In exploratory analyses, the relationship between AL and depressive symptoms was only significant among survivors with a lower income. In contrast, in survivors in the highest income group, depressive symptoms were lower and unrelated to AL.Conclusion: High AL is associated with more depressive symptoms among cancer survivors.Implications for practice: Nurses have an important role in identifying psychological distress in cancer patients and survivors. Further research is needed to investigate the usefulness of AL as a marker in the context of cancer follow-up care and screening for psychological distress.
%K Allostasis
%K Cancer survivors
%K Confidence intervals
%K Depression
%K Diagnosis
%K Glucose
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