RT Journal Article
T1 Computational Methods and Software Tools for Functional Analysis of miRNA Data
A1 Garcia-Moreno, Adrian
A1 Carmona-Saez, Pedro
K1 Functional analysis
K1 MiRNA
K1 NcRNA
K1 Databases
K1 Enrichment
K1 Tools
K1 MicroARNs
K1 ARN largo no codificante
K1 Bases de datos genéticas
K1 Programas informáticos
AB miRNAs are important regulators of gene expression that play a key role in many biological processes. High-throughput techniques allow researchers to discover and characterize large sets of miRNAs, and enrichment analysis tools are becoming increasingly important in decoding which miRNAs are implicated in biological processes. Enrichment analysis of miRNA targets is the standard technique for functional analysis, but this approach carries limitations and bias; alternatives are currently being proposed, based on direct and curated annotations. In this review, we describe the two workflows of miRNAs enrichment analysis, based on target gene or miRNA annotations, highlighting statistical tests, software tools, up-to-date databases, and functional annotations resources in the study of metazoan miRNAs.
PB MDPI
YR 2020
FD 2020-08-28
LK http://hdl.handle.net/10668/3812
UL http://hdl.handle.net/10668/3812
LA en
NO Garcia-Moreno A, Carmona-Saez P. Computational Methods and Software Tools for Functional Analysis of miRNA Data. Biomolecules. 2020 Aug 28;10(9):1252
DS RISalud
RD Apr 6, 2025