RT Generic
T1 Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains
A1 Gonzalez-Calvo, Ines
A1 Cizeron, Melissa
A1 Bessereau, Jean-Louis
A1 Selimi, Fekrije
K1 synapse
K1 molecular conservation
K1 CCP
K1 CUB
K1 TSP-1
K1 invertebrates
K1 vertebrates
K1 Auxiliary subunit
K1 Kainate receptors
K1 Sushi domains
K1 Transmembrane protein
K1 Glutamate receptors
K1 Crystal-structure
K1 Hikaru-genki
K1 Drosophila
K1 Molecules
K1 Srpx2
AB The appearance of synapses was a crucial step in the creation of the variety of nervous systems that are found in the animal kingdom. With increased complexity of the organisms came a greater number of synaptic proteins. In this review we describe synaptic proteins that contain the structural domains CUB, CCP, or TSP-1. These domains are found in invertebrates and vertebrates, and CUB and CCP domains were initially described in proteins belonging to the complement system of innate immunity. Interestingly, they are found in synapses of the nematode C. elegans, which does not have a complement system, suggesting an ancient function. Comparison of the roles of CUB-, CCP-, and TSP-1 containing synaptic proteins in various species shows that in more complex nervous systems, these structural domains are combined with other domains and that there is partial conservation of their function. These three domains are thus basic building blocks of the synaptic architecture. Further studies of structural domains characteristic of synaptic proteins in invertebrates such as C. elegans and comparison of their role in mammals will help identify other conserved synaptic molecular building blocks. Furthermore, this type of functional comparison across species will also identify structural domains added during evolution in correlation with increased complexity, shedding light on mechanisms underlying cognition and brain diseases.
PB Frontiers media sa
YR 2022
FD 2022-04-25
LK http://hdl.handle.net/10668/20649
UL http://hdl.handle.net/10668/20649
LA en
DS RISalud
RD Apr 8, 2025