TY  - JOUR
AU  - Ocadlikova, Darina
AU  - Lecciso, Mariangela
AU  - Broto, Javier Martin
AU  - Scotlandi, Katia
AU  - Cavo, Michele
AU  - Curti, Antonio
AU  - Palmerini, Emanuela
PY  - 2021
DO  - 10.3389/fimmu.2021.577766
UR  - http://hdl.handle.net/10668/4011
T2  - Frontiers in Immunology
AB  - Background: High-grade sarcomas are a heterogeneous group of aggressive tumors arising in bone and soft tissues. After relapse, treatment options are limited. The multi targeted receptor tyrosine kinase inhibitors (TKIs) sunitinib and inhibitor of...
LA  - en
PB  - Frontiers
KW  - Osteosarcoma
KW  - Synovial sarcoma
KW  - Tyrosine kinase inhibitor (TKI)
KW  - Nivolumab
KW  - Sunitinib
KW  - Immunomodulation
KW  - Dendritic cell (DC)
KW  - T regulatory cells
KW  - Sarcoma sinovial
KW  - Inmunomodulación
KW  - Células dendríticas
KW  - Linfocitos T reguladores
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation
KW  - Medical Subject Headings::Anatomy::Cells::Antigen-Presenting Cells::Dendritic Cells
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Immunomodulation
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immunologic Techniques::Immunologic Tests::Immunophenotyping
KW  - Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Lymphocyte Activation
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Antigens, Differentiation::Antigens, Differentiation, T-Lymphocyte::Programmed Cell Death 1 Receptor
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors
KW  - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Lymphocyte Subsets::T-Lymphocyte Subsets
KW  - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes::T-Lymphocyte Subsets::T-Lymphocytes, Regulatory
TI  - Sunitinib Exerts In Vitro Immunomodulatory Activity on Sarcomas via Dendritic Cells and Synergizes With PD-1 Blockade
TY  - research article
ER  -