RT Journal Article
T1 Cardiovascular magnetic resonance determinants of ventricular arrhythmic events after myocardial infarction.
A1 Jáuregui, Beatriz
A1 Soto-Iglesias, David
A1 Penela, Diego
A1 Acosta, Juan
A1 Fernández-Armenta, Juan
A1 Linhart, Markus
A1 Ordóñez, Augusto
A1 San Antonio, Rodolfo
A1 Terés, Cheryl
A1 Chauca, Alfredo
A1 Carreño, José M
A1 Scherer, Claudia
A1 Falasconi, Giulio
A1 Prat-González, Susana
A1 Perea, Rosario J
A1 Mont, Lluís
A1 Bosch, Xavier
A1 Ortiz-Pérez, José T
A1 Berruezo, Antonio
K1 Arrhythmogenic substrate
K1 Border zone channels
K1 Cardiac magnetic resonance
K1 Myocardial infarction
K1 Scar arrhythmogenicity
K1 Ventricular arrhythmias
AB To non-invasively characterize, by means of late gadolinium enhancement cardiac magnetic resonance (LGE-CMR), scar differences, and potential variables associated with ventricular tachycardia (VT) occurrence in chronic post-myocardial infarction (MI) patients. A case-control study was designed through retrospective LGE-CMR data analysis of chronic post-MI patients (i) consecutively referred for VT substrate ablation after a first VT episode (n = 66) and (ii) from a control group (n = 84) with no arrhythmia evidence. The myocardium was characterized differentiating core, border zone (BZ), and BZ channels (BZCs) using the ADAS 3D post-processing imaging platform. Clinical and scar characteristics, including a novel parameter, the BZC mass, were compared between both groups. One hundred and fifty post-MI patients were included. Four multivariable Cox proportional hazards regression models were created for total scar mass, BZ mass, core mass, and BZC mass, adjusting them by age, sex, and left ventricular ejection fraction (LVEF). A cut-off of 5.15 g of BZC mass identified the cases with 92.4% sensitivity and 86.9% specificity [area under the ROC curve (AUC) 0.93 (0.89-0.97); P  The mass of BZC is the strongest independent variable associated with the occurrence of sustained monomorphic ventricular tachycardia in post-MI patients after adjustment for age, sex, and LVEF. Border zone channel mass measurement could permit a more accurate VT risk stratification than LVEF in chronic post-MI patients.
YR 2022
FD 2022
LK http://hdl.handle.net/10668/19776
UL http://hdl.handle.net/10668/19776
LA en
DS RISalud
RD Apr 7, 2025