RT Journal Article
T1 Clinical predictors for fatal pulmonary embolism in 15520 patients with venous thromboembolism - Findings from the Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) registry
A1 Laporte, Silvy
A1 Mismetti, Patrick
A1 Décousus, Hervé
A1 Uresandi, Fernando
A1 Otero, Remedios
A1 Lobo, Jose Luis
A1 Monreal, Manuel
K1 Death, sudden
K1 Prognosis
K1 Pulmonary embolism
K1 Thrombosis
K1 Anciano de 80 o más Años
K1 Estudios de cohortes
K1 Internacionalidad
K1 Valor predictivo de las Pruebas
K1 Estudios prospectivos
K1 Sistema de registros
K1 Factores de riesgo
K1 Trombosis de la vena
K1 Anciano
K1 España
AB BACKGROUNDClinical predictors for fatal pulmonary embolism (PE) in patients with venous thromboembolism have never been studied.METHODS AND RESULTSUsing data from the international prospective Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) registry about patients with objectively confirmed symptomatic acute venous thromboembolism, we determined independent predictive factors for fatal PE. Between March 2001 and July 2006, 15520 consecutive patients (mean age+/-SD, 66.3+/-16.9 years; 49.7% men) with acute venous thromboembolism were included. Symptomatic deep-vein thrombosis without symptomatic PE was observed in 58.0% (n=9008) of patients, symptomatic nonmassive PE in 40.4% (n=6264), and symptomatic massive PE in 1.6% (n=248). At 3 months, the cumulative rates of overall mortality and fatal PE were 8.65% and 1.68%, respectively. On multivariable analysis, patients with symptomatic nonmassive PE at presentation exhibited a 5.42-fold higher risk of fatal PE compared with patients with deep-vein thrombosis without symptomatic PE (P<0.001). The risk of fatal PE was multiplied by 17.5 in patients presenting with a symptomatic massive PE. Other clinical factors independently associated with an increased risk of fatal PE were immobilization for neurological disease, age >75 years, and cancer.CONCLUSIONSPE remains a potentially fatal disease. The clinical predictors identified in the present study should be included in any clinical risk stratification scheme to optimally adapt the treatment of PE to the risk of the fatal outcome.
PB American Heart Association
SN 0009-7322
YR 2008
FD 2008-04-01
LK http://hdl.handle.net/10668/1637
UL http://hdl.handle.net/10668/1637
LA en
NO Laporte S, Mismetti P, Décousus H, Uresandi F, Otero R, Lobo JL, et al. Clinical predictors for fatal pulmonary embolism in 15520 patients with venous thromboembolism: findings from the Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) Registry. Circulation. 2008; 117(13):1711-6
NO Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 6, 2025