RT Journal Article
T1 Biological Role of Nutrients, Food and Dietary Patterns in the Prevention and Clinical Management of Major Depressive Disorder.
A1 Ortega, Miguel A
A1 Fraile-Martínez, Óscar
A1 García-Montero, Cielo
A1 Alvarez-Mon, Miguel Angel
A1 Lahera, Guillermo
A1 Monserrat, Jorge
A1 Llavero-Valero, Maria
A1 Gutiérrez-Rojas, Luis
A1 Molina, Rosa
A1 Rodríguez-Jimenez, Roberto
A1 Quintero, Javier
A1 De Mon, Melchor Alvarez
K1 dietary interventions
K1 major depressive disorder (MDD)
K1 omega 3 polyunsaturated fatty acids
K1 polyphenols
AB Major Depressive Disorder (MDD) is a growing disabling condition affecting around 280 million people worldwide. This complex entity is the result of the interplay between biological, psychological, and sociocultural factors, and compelling evidence suggests that MDD can be considered a disease that occurs as a consequence of an evolutionary mismatch and unhealthy lifestyle habits. In this context, diet is one of the core pillars of health, influencing multiple biological processes in the brain and the entire body. It seems that there is a bidirectional relationship between MDD and malnutrition, and depressed individuals often lack certain critical nutrients along with an aberrant dietary pattern. Thus, dietary interventions are one of the most promising tools to explore in the field of MDD, as there are a specific group of nutrients (i.e., omega 3, vitamins, polyphenols, and caffeine), foods (fish, nuts, seeds fruits, vegetables, coffee/tea, and fermented products) or dietary supplements (such as S-adenosylmethionine, acetyl carnitine, creatine, amino acids, etc.), which are being currently studied. Likewise, the entire nutritional context and the dietary pattern seem to be another potential area of study, and some strategies such as the Mediterranean diet have demonstrated some relevant benefits in patients with MDD; although, further efforts are still needed. In the present work, we will explore the state-of-the-art diet in the prevention and clinical support of MDD, focusing on the biological properties of its main nutrients, foods, and dietary patterns and their possible implications for these patients.
YR 2022
FD 2022-07-28
LK http://hdl.handle.net/10668/21492
UL http://hdl.handle.net/10668/21492
LA en
DS RISalud
RD Apr 8, 2025